Question: Hi, my brother-in-law has nearly all of these symptoms: Hand and arm symptoms. At first you may notice that your grip is less strong. You may drop things and find it difficult to open bottle tops, turn keys, etc. You may also notice that the muscles in your hands (especially at the base of your thumbs) become flatter with time.
Feet and leg symptoms. At first you may start to drag one leg or tend to trip easily. You may find it more difficult to climb stairs or rise out of low chairs. You may find you are much more tired after walking.
Bulbar muscle symptoms. You may not be able to shout or sing. Your speech may become slurred. There may be a change in the quality of your voice. You may experience some difficulties with swallowing as the muscles which co-ordinate swallowing become affected.
Other symptoms that may occur include: muscle cramps, tiredness, twitching of weakened muscles (fasciculation) and jerking of an arm or leg whilst you rest.

How do symptoms progress?
Symptoms may affect just one arm or leg at first. They then gradually become worse and spread to involve other limbs. Eventually, many muscles in the body become affected. Some muscle groups may be more badly affected than others. Muscles gradually become weaker and wasted. The problems that develop may eventually include the following:

Walking (mobility) typically becomes worse.
Doing tasks with your arms and hands becomes increasingly difficult.
Eating and swallowing become difficult when the tongue and the muscles around the mouth and throat become weak.
Sneezing and coughing become weak.
You may become breathless on minimal exertion when the chest muscles become affected.

Doctors are puzzled and have not and will not give him a diagnosis. Do you think this is XXXXXXX Gehrig's Disease?