Hi, thanks for using healthcare magicAlkaline phosphatase
is one of the enzymes normally seen in the body. It is responsible for removing phosphates (which is a combination of phosphorus and oxygen) from different molecules.
It is concentrated in the liver, bile ducts (these are present in the liver ), kidney and bone.
A low ALP is uncommon. There are a number of potential causes for a low ALP such as deficiency in zinc or magnesium, nutritional deficiency
, low levels of thyroid hormone, aplastic anemia
and vitamin c deficiency
. It can also occur in some leukemias but in that case the white cell count is more likely to be elevated.
Aplastic anemia is a condition where the bone marrow
does not produce enough cells and it results in low blood count, low white cell count and low platelets since all of these are made in the marrow.
Hypophosphatasia is a condition where is there an error in the gene that is suppose to order/make alkaline phosphatase. It would present with a history of loss of delayed walking, early loss of the baby teeth and bone pain.
Pernicious anemia is a condition where there is failure to absorb vitamin b 12.
It may be a lab error and the doctor may likely repeat the labs to ensure that they are accurate.
If the repeat values are also similarly abnormal then further investigations would be conducted.
The blood tests would include magnesium, zinc, thyroid hormone levels, calcium (this would be high in hypophosphatasia), phosphorus , creatinine(checks the kidneys)
The low white cell may occur aplastic anemia which was mentioned earlier and in some vitamin deficiencies like vitamin b 12 deficiency.
The exact treatment would depend on the cause.
I hope this helps, feel free to ask any other questions