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How Does Food Affect Oxycontin?

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Posted on Mon, 8 Dec 2014
Question: I take oxycontin 40 MG table x8 hours for chronic back/neck pain. When I eat a meal before or after taking the medication I loose the effectiveness of the pain medicine. Can you explain how eating affects the release of the medication?
doctor
Answered by Dr. Muhammad Ali Rauf (1 hour later)
Brief Answer:
Food impairs absorption from stomach

Detailed Answer:
Hello

My name is Dr Muhammad Ali Rauf & i will look into your problem.

I have gone through your query and would try to help you in the best possible way.
Certain food decreases the rate of absorption of drug in stomach, as a result desirable effects are not achieved. oxycontin contains oxycodone which is a strong analgesic. Most of the food except fatty meal decreases its absorption from stomach mucosa. As it stays for longer time in stomach so gastric secretions decreases its effectiveness.
You mentioned about absorption of drug from liver, liver's main role is metabolism. There are a number of enzymes in liver whose function are to metabolize drugs and convert it to inactive form. After metabolism it is then excreted. In your case, 83% oxycodone is eliminated through urine by action of an enzyme present in liver.

> For Maximum effect:
To achieve maximum effects of oxycontin, take it with water and do not eat food 30mins before or after meal. Fatty meal can be taken because research has shown that fatty meal increases its absorption & potentiates its effect.

Hope I have answered your query. If you have any further questions I will be happy to help if not then don't forget to close the discussion and rate it.
Wishing you good health !!
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Muhammad Ali Rauf (6 hours later)
I don't understand, for maximum effect, take it with water and do not eat food 30 mins before or after meal.
doctor
Answered by Dr. Muhammad Ali Rauf (29 minutes later)
Brief Answer:
Typing mistake

Detailed Answer:
Hello

Sorry for the typing mistake. I meant that you should take medicine with water and do not take food 30 mins before or after taking medicine.

Hope I have answered your query. If you have any further questions I will be happy to help if not then don't forget to close the discussion and rate it.
Wishing you good health !!
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Yogesh D
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Answered by
Dr.
Dr. Muhammad Ali Rauf

General & Family Physician

Practicing since :2013

Answered : 1312 Questions

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How Does Food Affect Oxycontin?

Brief Answer: Food impairs absorption from stomach Detailed Answer: Hello My name is Dr Muhammad Ali Rauf & i will look into your problem. I have gone through your query and would try to help you in the best possible way. Certain food decreases the rate of absorption of drug in stomach, as a result desirable effects are not achieved. oxycontin contains oxycodone which is a strong analgesic. Most of the food except fatty meal decreases its absorption from stomach mucosa. As it stays for longer time in stomach so gastric secretions decreases its effectiveness. You mentioned about absorption of drug from liver, liver's main role is metabolism. There are a number of enzymes in liver whose function are to metabolize drugs and convert it to inactive form. After metabolism it is then excreted. In your case, 83% oxycodone is eliminated through urine by action of an enzyme present in liver. > For Maximum effect: To achieve maximum effects of oxycontin, take it with water and do not eat food 30mins before or after meal. Fatty meal can be taken because research has shown that fatty meal increases its absorption & potentiates its effect. Hope I have answered your query. If you have any further questions I will be happy to help if not then don't forget to close the discussion and rate it. Wishing you good health !!