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How Can Ceftriaxone Be Administered Into The Body?

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Posted on Wed, 28 Oct 2015
Question: (1) If a patient has suspected sepsis and is administered ceftriaxone 1g then does it make any difference with regard to efficaciousness if the antibiotic is administered rapidly into a canulla, administered by slow drip or administered intra muscularly? (2) Typically, how long does it take to administer IV ceftriaxone 1g by slow drip (rougly how many minutes)? (3) If a patient needs to be on a saline solution for sepsis to avoid dehydration then are there any potential problems in adding the ceftriaxone to the saline solution at the same time?
doctor
Answered by Dr. Indranil Ghosh (1 hour later)
Brief Answer:
short IV push is preferred

Detailed Answer:
Hi
Thanks for your query.

Ceftriaxone is recommended to be administered as short IV push injection or intramuscular. There is not much difference in efficacy but higher doses are usually given IV as intramuscular would require too many pricks. It is not required to give ceftriaxone in a slow drip in 50-100 ml saline over 1/2 to 1 hr but it can surely be given like that. No difference in efficacy is expected.

In IV push it has to be given over 2-5 min.

Giving ceftriaxone in IV fluids over 4-6 hr has not been studied and hence not recommended.

Hope this helps.
Regards
Above answer was peer-reviewed by : Dr. Raju A.T
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Follow up: Dr. Indranil Ghosh (30 hours later)
Thank you kindly Dr. XXXXXXX for your very clear and informative answers. May I ask one more related question? If it is not recommended to add ceftriaxone to a saline solution then could an IV administration of ceftriaxone and IV fluids be administered SEPARATELY at the same time? Or would it be unusual or ridiculous to use two different canulla at the same time?
doctor
Answered by Dr. Indranil Ghosh (2 hours later)
Brief Answer:
yes it would be unnecessary

Detailed Answer:
The usual practice is to continue the IV fluids as required and at the time of ceftriaxone administration to stop it, give the injection as short IV push and then restart the IV fluids.

This can be done by a three way connector so that no tubing has to be removed.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Indranil Ghosh

Oncologist

Practicing since :2004

Answered : 1709 Questions

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How Can Ceftriaxone Be Administered Into The Body?

Brief Answer: short IV push is preferred Detailed Answer: Hi Thanks for your query. Ceftriaxone is recommended to be administered as short IV push injection or intramuscular. There is not much difference in efficacy but higher doses are usually given IV as intramuscular would require too many pricks. It is not required to give ceftriaxone in a slow drip in 50-100 ml saline over 1/2 to 1 hr but it can surely be given like that. No difference in efficacy is expected. In IV push it has to be given over 2-5 min. Giving ceftriaxone in IV fluids over 4-6 hr has not been studied and hence not recommended. Hope this helps. Regards