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Hello, I Am Frustratingly Searching For The Answer To A
Question: Hello,
I am frustratingly searching for the answer to a fairly simple question I thought. I have primary amenorrhea - genetic. Doctors wonder if XXXXXXX syndrome but I have no other symptoms besides tiny ovaries.
From 14-38, I've been on 1.25 Premarin and 5mg medroxyprogesterone (mp) cyclically with one week off. From 38-40 I went to half dose .625 Premarin and 2.5mg mp. Then Pfizer made a new version of the drug and at 40, I wasn't tolerating it. I developed hypothyroidism and I stopped taking the HRT. I have had a lot of side effects from the HRT over the years, but it was only at this point that I stopped and started trying bioidentical hormone therapy via estradiol cream and progesterone cream. I am also on thyroid medication now. The bioidentical treatment is not working for me and I am now suffering from arthritis symptoms and all the side effects that come with low to no estrogen/progesterone in my system.
I would like to try the synthetic HRT again, but this time at much lower doses, and continuously (instead of cyclically). I'd like to try the lowest dose I can manage. I understand that continuously, I'd likely need to take prempro and that the doses are as follows:0.3 mg-1.5 mg; 0.45 mg/1.5 mg; 0.625 mg-2.5 mg; or 0.625 mg-5 mg).
Is .3mg-1.5mg a good starting point? Do I take every day?
If I were to do cyclically, is there a lower dose than .625 Premarin/2.5 provera taken for 13 days.
I will take your information back to my hormone specialist. She is not a specialist in synthetics so is not familiar with dosing.
I am frustratingly searching for the answer to a fairly simple question I thought. I have primary amenorrhea - genetic. Doctors wonder if XXXXXXX syndrome but I have no other symptoms besides tiny ovaries.
From 14-38, I've been on 1.25 Premarin and 5mg medroxyprogesterone (mp) cyclically with one week off. From 38-40 I went to half dose .625 Premarin and 2.5mg mp. Then Pfizer made a new version of the drug and at 40, I wasn't tolerating it. I developed hypothyroidism and I stopped taking the HRT. I have had a lot of side effects from the HRT over the years, but it was only at this point that I stopped and started trying bioidentical hormone therapy via estradiol cream and progesterone cream. I am also on thyroid medication now. The bioidentical treatment is not working for me and I am now suffering from arthritis symptoms and all the side effects that come with low to no estrogen/progesterone in my system.
I would like to try the synthetic HRT again, but this time at much lower doses, and continuously (instead of cyclically). I'd like to try the lowest dose I can manage. I understand that continuously, I'd likely need to take prempro and that the doses are as follows:0.3 mg-1.5 mg; 0.45 mg/1.5 mg; 0.625 mg-2.5 mg; or 0.625 mg-5 mg).
Is .3mg-1.5mg a good starting point? Do I take every day?
If I were to do cyclically, is there a lower dose than .625 Premarin/2.5 provera taken for 13 days.
I will take your information back to my hormone specialist. She is not a specialist in synthetics so is not familiar with dosing.
Brief Answer:
Yes,0,371,5 mg can be a good starting point.
Detailed Answer:
Hello there,
I have gone through your query and underdstood your concern.
Premarin is a medication that contains 2 female hormones: estrogen and a progestin.
It is used by women to help reduce symptoms caused by the body making less estrogen.
This drug is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.
Arthritis is not a common sign of low estrogen and progesterone level. Anyway there a correlation between osteoarthritis and estrogen deficiency.
Considerating the potential side effects of HRT, I suggest taking the minimal doses that control the symptoms of your low estrogen( hot flashes, night sweats, insomnia or amenorrhea)
You can start the regimen with Prempro strengths (0.3 mg-1.5 mg) 1 tablet taken once a day.
This regimen is more practical than the regimen with two separate tablets taken sequentially: Conjugated estrogen doses 0,626 mg) taken once a day on days 1 through 14and a combined conjugated estrogen-medroxyprogesterone taken once a day on days 15 through 28.
You can decide which is the most appropriate regimen for you.
I want to underline that the lowest effective dose for the shortest duration is recommended.
Periodically re-evaluations as clinically indicated are necessary to determine if treatment is still necessary.
The follow up with a hormone specialist is very important for you to monitor and analyze the benefits/side effect and to guide you to adjust the doses and to decide the duration of current synthetic hormone therapy.
Hope this is helpful.
Let me know if i can assist you further.
Yes,0,371,5 mg can be a good starting point.
Detailed Answer:
Hello there,
I have gone through your query and underdstood your concern.
Premarin is a medication that contains 2 female hormones: estrogen and a progestin.
It is used by women to help reduce symptoms caused by the body making less estrogen.
This drug is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.
Arthritis is not a common sign of low estrogen and progesterone level. Anyway there a correlation between osteoarthritis and estrogen deficiency.
Considerating the potential side effects of HRT, I suggest taking the minimal doses that control the symptoms of your low estrogen( hot flashes, night sweats, insomnia or amenorrhea)
You can start the regimen with Prempro strengths (0.3 mg-1.5 mg) 1 tablet taken once a day.
This regimen is more practical than the regimen with two separate tablets taken sequentially: Conjugated estrogen doses 0,626 mg) taken once a day on days 1 through 14and a combined conjugated estrogen-medroxyprogesterone taken once a day on days 15 through 28.
You can decide which is the most appropriate regimen for you.
I want to underline that the lowest effective dose for the shortest duration is recommended.
Periodically re-evaluations as clinically indicated are necessary to determine if treatment is still necessary.
The follow up with a hormone specialist is very important for you to monitor and analyze the benefits/side effect and to guide you to adjust the doses and to decide the duration of current synthetic hormone therapy.
Hope this is helpful.
Let me know if i can assist you further.
Above answer was peer-reviewed by :
Dr. Arnab Banerjee
Hello
Thank you for your response.
I was hoping I could take even lower doses of prempro but it seems that is not feasible. TAB AVIANNE was also discussed as an option, as I can begin this treatment at lower doses. Is this an option? Which option is better in my case do you think?
Thank you for your response.
I was hoping I could take even lower doses of prempro but it seems that is not feasible. TAB AVIANNE was also discussed as an option, as I can begin this treatment at lower doses. Is this an option? Which option is better in my case do you think?
Brief Answer:
Yes,you can try.
Detailed Answer:
Hi again
I appologise gfor the late reply.
Aviane 28 is a combination birth control pill that contain ethinyl estradiol 0,02 mg and levonorgestrel 0,1 mg.
Aviane is used as contraception to prevent pregnancy.
In your case it can be an alternative of hormone replacement therapy with low dosis of estrogen and progestin.
-The best option in your case is the drug that contain the lower dosis of female hormons and in the same time that controll your symptoms of low estrogen/progresteron.
You can test Avianne for two or three cycles of treatement(2-3 months) and you can understand if this alternative is enough or not to optimize your female hormone levels.
Hope i have clarified your doubts.
Wish you al the best.
Yes,you can try.
Detailed Answer:
Hi again
I appologise gfor the late reply.
Aviane 28 is a combination birth control pill that contain ethinyl estradiol 0,02 mg and levonorgestrel 0,1 mg.
Aviane is used as contraception to prevent pregnancy.
In your case it can be an alternative of hormone replacement therapy with low dosis of estrogen and progestin.
-The best option in your case is the drug that contain the lower dosis of female hormons and in the same time that controll your symptoms of low estrogen/progresteron.
You can test Avianne for two or three cycles of treatement(2-3 months) and you can understand if this alternative is enough or not to optimize your female hormone levels.
Hope i have clarified your doubts.
Wish you al the best.
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.
Above answer was peer-reviewed by :
Dr. Raju A.T
Answered by
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