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Dr. Andrew Rynne

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Does Sulfamethoxazole interact with Digoxin and Losartan?

Answered by
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Dr. Noble Zachariah

Internal Medicine Specialist

Practicing since :1974

Answered : 2251 Questions

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Posted on Sat, 3 Sep 2016 in Medicines and Side Effects
Question: Hi doctor. I am currently undergoing treatment in my feet for infection/ circulation problems. I have had two toes amputated recently. My foot is swelling and red and I wanted to take sulfamethox/t. However I also have a heart condition. Am taking digoxin and losartan. Can I take the antibiotic while on those heart medications or are there contraindications?
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Answered by Dr. Noble Zachariah 1 hour later
Brief Answer:
Adverse interactions possible

Detailed Answer:
Hello,

Welcome and thanks for your query.
Sulfamethoxazole has adverse interactions with both digoxin and losartan due to its effect on the liver metabolic pathways and renal clearance.
Better to avoid. Levofloxacin does not have this effect and may be a better option.
Please check with your doctor
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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