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Does Lamictal Interact With Trileptal?

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Posted on Fri, 20 Jan 2017
Question: I am on Lamictal 200mg and Trileptal 300mg. My hormone Dr has me on 200 mg of progesterone, but have read my prescriptions cancel each other out. I need to understand how these medications interact with each other. I only take the progesterone days 14-21 of my cycle.
doctor
Answered by Dr. Alexander H. Sheppe (50 minutes later)
Brief Answer:
Consultation

Detailed Answer:
Hello, and thanks for your question.

There is no serious contraindication or interaction between progesterone, Lamictal, and Trileptal. They can sometimes interact in a minor way to change each others' concentration in the blood, but this is not a reason not to use them together.
Please remember to rate and close this answer thread when you are finished and satisfied.

In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers

Brief Answer:
Followup

Detailed Answer:
They do not cancel each other. They have small effects, if any, on blood levels. I believe oral contraceptives are effective, so you might want to consider these instead of progesterone if you are especially concerned.

Please remember to rate and close this answer thread when you are finished and satisfied.

In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers
Above answer was peer-reviewed by : Dr. Prasad
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Follow up: Dr. Alexander H. Sheppe (2 hours later)
Do you feel for PMDD it's better to use oral contraceptives over progesterone? My symptoms are severe but the web states they will cancel each other 40-60 % with Lamictal and Trileptal. Trying to find an answer for treating depression, anxiety and PMDD. I can't take SSRI's I've tried every one and they make me worse/suicidal. This is all so confusing and frustrating. If only western medicine could be on the same page. The pharmacist stated I would have to double my Lamictal and Trileptal if I went on birth control or used progesterone. If it does diminish levels in the blood, wouldn't that signify needing to augment with a high dose? Trying to fulling understand. Hello Dr.

Let me ensure I'm being clear. I started processing sexual abuse from my childhood. During my trauma treatment my dr started me on Lamictal and Trileptal to help with the depression and anxiety I was experiencing. I also had on0set PMDD, I would imagine related to dealing with "sexual abuse". The combination of the two has been overwhelming as I have always been a highly successful business woman. In treating these three symptoms PTSD-anxiety and depression, and PMDD what could be the best way to use these medications together. In reading on-line, and also the feedback from the pharmacist, they state they I would need to double my prescription of trileptal and lamictal if I use birth control. If I need to up the dose (if on birth control) I really need to understand that as when I haven't had a full dose I suffer severe side effects. Thank you!
doctor
Answered by Dr. Alexander H. Sheppe (17 hours later)
Brief Answer:
Followup

Detailed Answer:
I disagree with the pharmacist that you would need to double the dose. I would talk with your prescribing doctor about their opinion on the matter. My understanding is that the dose would likely not need to be changed, but to monitor this you would first need to get blood levels of the medication after starting the progesterone.

Please remember to rate and close this answer thread when you are finished and satisfied.

In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Alexander H. Sheppe (19 hours later)
I posed my question to another Dr on this web-site and he was insistent they will interfere and it is not recommended. Hense my confusion and frustration. Leaves me not knowing what to do or how to treat my PMDD. Any other thoughts would be greatly appreciated.
doctor
Answered by Dr. Alexander H. Sheppe (4 hours later)
Brief Answer:
Followup

Detailed Answer:
The other doctor and I are in agreement that the levels would be changed. However, I do not believe this should influence treatment. Simply take all the medications and check their blood levels in a couple weeks, and make adjustments as indicated.

Please remember to rate and close this answer thread when you are finished and satisfied.

In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers
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Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Alexander H. Sheppe

Psychiatrist

Practicing since :2014

Answered : 2236 Questions

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Does Lamictal Interact With Trileptal?

Brief Answer: Consultation Detailed Answer: Hello, and thanks for your question. There is no serious contraindication or interaction between progesterone, Lamictal, and Trileptal. They can sometimes interact in a minor way to change each others' concentration in the blood, but this is not a reason not to use them together. Please remember to rate and close this answer thread when you are finished and satisfied. In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers Brief Answer: Followup Detailed Answer: They do not cancel each other. They have small effects, if any, on blood levels. I believe oral contraceptives are effective, so you might want to consider these instead of progesterone if you are especially concerned. Please remember to rate and close this answer thread when you are finished and satisfied. In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers