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Can Carbidopa,Carvedilol,Spironolactone,Potassium Chloride And Digoxin Be Taken Together?

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Posted on Fri, 26 Sep 2014
Question: Yes…my husband is on a number of drugs for many health issues. I feel he is being over-medicated
because he feels dizzy, lightheaded and his balance is not good. He takes pills from 6 a.m. until 8:30 p.m.
every day of the week. He has Parkinson's disease, congestive heart failure, high blood pressure
and cholesterol problems. He has a Parkinson's doctor and a GP. It is possible to contact someone
that can review his medications and see if there might be some interactions with his drugs? I sent a list
to his doctor, in fact, I faxed the list and he reviewed them and only cut down the Digoxin he was taking
twice a day which was 250 MG. I am very concerned.

Thank you.

XXXX
doctor
Answered by Dr. Prakash H Muddegowda (3 hours later)
Brief Answer:
Do send the list

Detailed Answer:
Hi XXXX
Thanks for asking.

Do send me list of medications, doses, schedule and indications. I will try to help you as much as possible.

Regards

Dr. Prakash HM
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Prakash H Muddegowda (10 hours later)
Dear Dr. Muddegowda,

This is a list of the medications my husband XXXXXXX is now taking:

Carbidopa-Levodopa 25-250 MG
Four times a day - 6 a.m., 10 a.m., 2 p.m. and 6 p.m.

Carvedilol - 6.25 MG
Two times a day - 6 a.m. and 4 p.m. This pill seems to make
him very tired and once he takes it he goes back to bed until
10:30 a.m.

Spironolactone - 25 MG
One pill - 6 a.m.

Potassium Chloride - 10 MEQ
One a day at 9 a.m.

Modafinil - 200 MG
10 a.m. - once a day

Furosemide - 20 MG
10 a.m. - one a day

Amantadine - HCI 100 MG
Breakfast and Lunch

Namenda XR 24 hours - 28 MG
10 a.m.

Digoxin - 250 MCG
6 p.m.

Alprazolam - 0.5 MG
8:30 p.m.

Tamsulosin - HCI 0.4 MG
6 p.m.

Carbidopa-Levodopa - ER 50-200 MG
8:30 p.m.

Vitamins: CoQ-10 200 MG, Ultimate GI Solutions for digestion, Mucus
Relief, Healthy Vision Complete.

My husband has had Parkinson's disease for over ten years. He goes to
therapy one day a week so they can keep him limber. He has a shuffle
when he walks. His balance is not good and he is unsure of himself that
his legs will get him very far. He sits on the couch and has no energy to
do much. He has a good appetite and does not miss any meals.

I would sure appreciate any suggestions you can give me as to what you
think about Jack's drugs. It just seems to me that he would do much better
with less. He seems to feel okay when he gets up in the morning and as the day goes on he gets worse.

Best regards,

XXXX


doctor
Answered by Dr. Prakash H Muddegowda (14 hours later)
Brief Answer:
Too many medications.

Detailed Answer:
Hi XXXX
Thanks for asking again.

This sure is a long list of drugs.

Most of them are CNS related medications and their main function is reduce CNS activity -- Carbidopa, levodopa, Amanatidine are for Parkinsonism. While Namenda-XR is for Alzheimer's disease. -- These are all in particular and Namenda specifically causing his balance and worsening CNS problems. Removing any of these medications can cause exacerbated neurological and psychological problems.

Carvedilol, Digoxin and Spirolactone, all perform different functions in stabilizing the heart in cardiac failure. Furosemide is one drug indicated in pedal edema. If he does not have pedal edema, and his blood pressure is under control, it can be put on hold. Edema, when it recurs, Furosemide can be started. In the mean time limb elevation at night can be helpful.

Alprazolam is used for sleep induction. It can be used as required. If you think, he is not getting good sleep, then you can use Alprazolam. Otherwise, not necessary.

Tamsulosin, is for prostate related problems. If he is able to urinate properly and has no retention, then it can be withdrawn. However, if there is urinary incontinence, risk of urinary infection and with these problems, it can become critical.

Modafinil is expected to improve mood and CNS activity. Looking at the symptoms, you can discuss with your doctor regarding his lowering activity and if it is serving its function.

Good nutrition can supplement vitamins.
Getting actively involved in day to day and social activities, despite his CNS problems, should improve symptoms.


As I have limited knowledge of XXXXXXX symptoms at present, I can only leave it to your judgement. Look at the symptoms, discuss with your doctor and decide.

Hope it helps.
Take care.
Any further queries, happy to help again

Regards,
Dr. Prakash HM

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Prakash H Muddegowda (9 hours later)
Thank you very much for the information you have supplied on Jack's medication.
It is helpful to review the drugs with you.

My husband just had a full blood panel done last week. I have the results.
Would it be helpful to you to know some of the results? If so, please let
me know and I will send the information to you. The doctor said that Jack's
congestive heart failure has cleared, except for a small rattling in his right
lung. I had not received your report before his appointment yesterday.
His doctor said that I could cut out the Carbidopa-Levodopa at 6 a.m. and
2 p.m. and also he has reduced the dosage of the Carvedilol to 3.125 mg. He also
cut out the Amantadine at my request. I suspect that this is the pill that makes
my husband dizzy. I am concerned that cutting out the Carbidopa-Levodopa might cause my husband to shake more. When he takes this pill it seems to quite down
the shaking.

Getting these pills right, I fee,l is a crap shoot. My husband only has one hobby and that is limited golf. For the last month he hasn't even wanted to go to the golf course because he doesn't have the energy. He told the doctor yesterday that
he feels like he is all in all the time and that is why he sits on the couch. I insist that he go to therapy one day a week. He resists that; however, I do see an improvement in him when I pick him up. He does not carry on a conversation with people because he says he forgets things and has nothing to say. Several years ago he was much more interested in life and these days he seems not to care about much that is going on around him.

Again, I think you for your input. It is very helpful to me.

Best regards,

XXXX
doctor
Answered by Dr. Prakash H Muddegowda (2 hours later)
Brief Answer:
Watch closely and improve diet.

Detailed Answer:
Hi XXXX
Thanks for asking again.

Amongst the blood panel, if hemoglobin level and albumin level are normal, its adequate.
I would not require anything else as he is physically fully well.

Watch him over closely for at least a week regarding Amanatidine withdrawal. Yes, it definitely was one of the cause, but Namenda would have been the bigger one.

Since, he had all symptoms of Alzheimer's, there is no question of removing Namenda. Medication are important to improve quality of life of patient and caregiver.

If the fluids are clearing, that's good news.

Improve his nutrition especially with vit A&E through diet. Again I stress, family and friends support is essential. Try to make him socially active. This stimulus is much more than any medication and will comfort him well.

Any further queries, happy to help again.

If you do not have any further queries, you can close the discussion and rate the answer.

Take care.
Dr. Prakash HM
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Prakash H Muddegowda

Geriatrics Specialist

Practicing since :2004

Answered : 2138 Questions

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Can Carbidopa,Carvedilol,Spironolactone,Potassium Chloride And Digoxin Be Taken Together?

Brief Answer: Do send the list Detailed Answer: Hi XXXX Thanks for asking. Do send me list of medications, doses, schedule and indications. I will try to help you as much as possible. Regards Dr. Prakash HM