Hi Doc, I got a Skin Sparing Mastectomy done on my right breast on March 30th, 2011 as the tumour was malignant. Post that i completed my 8 cycles of Dose-Dense Chemotherapy followed by 28 fractions of radiation therapy. My ER & PR were positive & hence now i am on hormone therapy taking 1 (10mg) tablet of Tamoxifen daily & will have to do so for the next 5 years. My Onco yesterday also advised that i get Injection Zoladex for 2 years (@ 3.6 mg monthly or 10.8 mg quarterly). I am 36 years unmarried. I do understand that zoladex will suppress the function of the ovaries for 2 years. I have attached my post surgical report. My ques:1) Basis my report is it advisable to get Zoladex shots ? and for a duration of 2 years ?2) Why is 2 years considered an ideal period for the Injections & not 3 or 4 years ?3) What is the difference in function of Tamoxifen & Injection Zoladex ?4) And kindly advise the follow up treatments in my case with the periodicity.Look forward to hearing from you.Brgds, Pallavi