Hello Mr. Brunell, Thanks for writing in. Although irregular cycles ( with irregular amounts of bleeding) is common in uncontrolled polycystic ovarian disease, the possibility of pregnancy needs to be ruled out. I would suggest the following ( please follow this in a step wise manner to get to the real cause in the most cost effective and least troublesome manner) a. Get a urine pregnancy test done for your wife. If positive, she needs an ultrasound to see if she has had a complete abortion. If yes, then she is good. If the abortion is incomplete, she will need a dilation and curettage to get rid of the remaining products of conception. b. If the urine pregnancy test is negative, I would suggest she see her gynaecologist. If she wants to conceive, she would need to lose weight and continue with metformin. Hope this helps. Regards