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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Does My Blood Test Report Indicate?

I AM A 17 YEAR CANCER SURVIVOR OF PAGET S DISEASE OF THE NIPPLE. ON A RECENT BLOOD TEST A DR MENTIONED THAT SHE QUESTIONS IF MY PAGET S IS BACK BECAUSE OF A HIGH RESULT ON THE COMPONENT ALKALINE FROM A HEPATIC PANEL. THE DR SAID THAT CURRENTLY THAT IS A NEW INDICATOR OF PAGET S. I HAVE NOT HAD ANY LUMPS THAT I HAVE NOTICED AND THE LAST 3 YEARS THE AFFECTED BREAST HAS GONE THROUGH A MAMMOGRAM WITH NOTHING ABNORMAL REPORTED. WOULD ANYONE WITH CURRENT KNOWLEDGE ON THIS TYPE OF BREAST CANCER CARE TO COMMENT. I D REALLY APPRECIATE IT. THANKS FOR YOUR HELP!!
Thu, 21 Mar 2019
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Radiologist 's  Response
Hi,

There are more than one Paget disease and I guess there is a misunderstanding in your situation. Paget disease of the breast is ductal carcinoma (in situ or invasive) that goes through milk channels and reaches the nipple. It can be seen in other parts of the body not only breast.

The other Paget disease is a bone metabolism disease that bone cells cycle gets faster and causes fragile, deform bones. In this Paget disease, ALP (alkaline phosphatase) is very valuable blood indicator.

But ALP is not spesific for Paget disease of breast. In your case mild rising of ALP may indicate fatty liver, biliary tract problems or other liver diseases. Other studies like ultrasound, serology, additional blood test may done if there is a clinical suspect. If there is no additional findings a control blood test for ALP would be enough.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. HAMZA EREN GUZEL, Radiologist
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What Does My Blood Test Report Indicate?

Hi, There are more than one Paget disease and I guess there is a misunderstanding in your situation. Paget disease of the breast is ductal carcinoma (in situ or invasive) that goes through milk channels and reaches the nipple. It can be seen in other parts of the body not only breast. The other Paget disease is a bone metabolism disease that bone cells cycle gets faster and causes fragile, deform bones. In this Paget disease, ALP (alkaline phosphatase) is very valuable blood indicator. But ALP is not spesific for Paget disease of breast. In your case mild rising of ALP may indicate fatty liver, biliary tract problems or other liver diseases. Other studies like ultrasound, serology, additional blood test may done if there is a clinical suspect. If there is no additional findings a control blood test for ALP would be enough. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. HAMZA EREN GUZEL, Radiologist