Hello, I have gone through your query and understand your concern. It could be either due to allergy to fabrics/bra or a paget s disease or infection. Paget s disease of the breast is a rare form of breast cancer in which the first clinical finding is usually a scaling of the nipple skin. It may also be associated with nipple redness and burning. The first step in evaluating any patient with a change in the skin of the nipple is to obtain a careful history and perform a careful breast examination, followed by a diagnostic mammogram. If the mammogram is negative and our clinical suspicion is low, we usually suggest that the patient place a cortisone cream on the nipple for two weeks. If the condition has not responded completely to conservative treatment in two weeks, we proceed to a skin punch biopsy. Most of our patients who do have a skin punch biopsy end up with a benign result. These patients simply require reassurance that there is no cancer present, and follow-up observation is all that is indicated. Sometimes a moisturizing cream is helpful to control any nipple dryness. If Paget s is positive, We remove the nipple (and any surrounding breast tissue) that contains breast cancer. Hope this helps. Please write back for further queries. Wishing you good health.