Hi I did review your concern. An elevated value of thyroid peroxidase antibody with a increased TSH level is indicative of Hashimotos thyroiditis. It is an autoimmune condition in which there is lymphocytic invasion and destruction of thyroid gland leading to mild neck swelling and hypothyroidism. you might feel sleepy, gain weight, feel less hungry, remain constipated and experience menstrual and skin and hair loss changes. However, the symptoms can be treated by using long term thyroxine tablets once in morning starting from low dose and titrating according to TSH levels. The disease per se is not treated as there is no know etiology as to why and how it begins. I hope this helps Wish you all the best Thank you for choosing healthcaremagic.