Hi, Thanks for writing to us, Intake of single/multiple drugs for a long duration and regularly can lead to complications of psychosis where an individual may start seeing or hearing imaginary things. Another complication may be a sensation of crawling insects on the skin which leads patients to pick their own skin. It appears that both these have affected your sister. In cases of overdose, the blood pressure can sometimes get altered leading to an imminent danger of a stroke. High blood pressure alone does not lead to any problem but if there is a consequent stroke, there can be long lasting problems like weakness of limbs or difficulty in speech. At this point, you can stay positive and hope for her full recovery at the earliest, Hope this answered your query, Dr Anjana Rao Kavoor