Hello, and I hope I can help you today. Contrary to what many may believe, many medications can be used safely during pregnancy without having any effect on the fetus. Many types of antibiotics, especially ones that are derived from penicillin, are completely safe to use during pregnancy. Furthermore, pain relievers like morphine and similar drugs can also be used safely during pregnancy. I am sure that the doctors caring for your daughter-in-law have taken into consideration her pregnancy when deciding what the best medical treatment is for her. If she has infection that is spread beyond her gallbladder, treating her properly is absolutely necessary for her to have a healthy pregnancy going forward. In addition, your daughters doctors advice about operating on her gallbladder during the second trimester is correct. This is the time when the fetus is big enough to be less at risk for the effects of any drugs or medications, and still small enough to make the surgery technically possible without manipulating the uterus. Gallbladder disease tends to get worse while a woman is pregnant because of the hormones, so it is very important that your daughter-in-law follow the doctor s recommendations. It is a common disease that is managed frequently by obstetricians. I am sure that her medical team has chosen antibiotics and other medications to use that will not cause harm to the fetus. I hope I was able to answer your question today, and that my advice was reassuring. Best wishes, and best of luck to your daughter-in-law with the pregnancy, Dr. Brown