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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Taking Suboxone. Can Prilosec inhibit suboxone?

Hi, I am concerned about interactions between certain perscription medications. What does it mean if a drug inhibits another drug? For instance, I am prescribed suboxone and while doing some research found on the SAMSA website that prilosec can inhibit suboxone? Does that mean there would be more active amounts of suboxone in the bloodstream, thus causing an increase of effects? I need to know because I am tapering off and also want to be safe. I also am learning as much as I can, as I am graduating from Penn State this May with a B.A. in Psychology and I plan to further my education with a master s degree in addictions counseling, or a master s in social work (MSW) or something of that nature because I want to work with clients who have substance abuse issues. Also, is it true that it has also been inadvertently discovered that suboxone (more likely the buprenorphine component itself) helps alleviate symptoms of depression in some people? I know it is not used for the treatment of depression in the U.S. but about 7 or 8 months ago I was doing some research and found that they were conducting studies in Israel to test the effectiveness of buprenorphine in treating individuals with Major Depressive Disorder . I can t remember how I came across that, but it was a reliable source (I know the difference and am currently doing my own research project at PSU). Any information would be greatly appreciated. One more thing, why isn t suboxone or buprenorphine approved for the treatment of moderate to severe pain? It is supposed to be 10-20 times more potent than morphine as an analgesic but far less addictive.
Thu, 31 Jan 2013
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General & Family Physician 's  Response
Hi,
there are drug interactions for sure. During prescriptions, the pharmacodynamics and pharmakinetics of these drugs are already known, and its up to the prescribing physician to master and know how and when to prescribe particular associations. Which respect to B. research in Israel, its true and tentative results are convincing. Remember that drugs have been used to treat one disease, but during the process, clinicians realize that patients with another disease report relieve from the unintended drug. You can read up the history of Misoprostol and its various indications. This simply causes researchers in the field to investigate this effect and tap its benefit.
As for depression, in the field of psychiatry, yu realize that most disorders turn about similar defects, either excesses or inadequate quantities of particular neurotransmitters. Changing the disage of a particular drug, changes its pharmacokinetics and pharmacodynamics, thus producing a different therapeutic outcome.
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