3 weeks after using Efudex cream on my nose, I started getting hives, no where in particular on the bottom side of my forearms, on the top of my feet to the extent that I wanted to scratch my skin off, lumps & bumps would appear. The area would welt up and inflame in no particular place. If I stood all day my quads would inflame welts or lumps would appear, my knees would ache so bad I couldn t stand. If I rested my arms on chair rests for any extended period of time the pressure points would welt up. The same would happen to my feet if I rested them on chair runners. If I bump myself or even get a sore throat it hurts way more (heaps) more then it did before. Pressure points are the worst. Seems I cant lean on anything for to long and it starts to ache. One particular time I swelled ached and itched that bad a doctor injected pethidine in my leg. The injection hurt so much and around the needle hole swelled up about 10- 12cm and raised up 3mm and was hot. Today 6 years later I still get mild reactions, aches, no welts but little red spots about 4mm in diameter might appear for no particular reason, say if some sparks from a grinder hit my under arm it will get itchy and hive up a little. My legs get restless at night from standing a lot. Even typing this my fore arm muscles are aching. I m not saying it is efudex but I had lots of test and its like they gave up and put it down to efudex. I don t wish to put up with this, so any advise would be great. Thanking you heaps Mark