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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Taking Mifepristone 200mg And Misoprostol 400mg Same Day Harmful?

My wife had taken mifepristone 200mg in the morning and taken the misoprostol 400mg oraly at night as directed by the physician on the same day, She is having abdominal pain and headache and little amount of bleeding also. Is that any sever problem? .....taking both pills on same day?
Mon, 23 Mar 2020
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General & Family Physician,  's  Response
Hi,

It may not be harmful but it may decrease their efficacy. The side effects of vomiting, bleeding and spotting in women who received misoprostol on the same day is significantly less compared with women who received misoprostol 48 hours after the mifepristone. However, taking mifepristone and misoprostol on the same day may not be effective at causing abortion within the first 24 hours compared with the standard time interval of 48 hours between medications.

Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Mohammed Taher Ali, General & Family Physician
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Is Taking Mifepristone 200mg And Misoprostol 400mg Same Day Harmful?

Hi, It may not be harmful but it may decrease their efficacy. The side effects of vomiting, bleeding and spotting in women who received misoprostol on the same day is significantly less compared with women who received misoprostol 48 hours after the mifepristone. However, taking mifepristone and misoprostol on the same day may not be effective at causing abortion within the first 24 hours compared with the standard time interval of 48 hours between medications. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali, General & Family Physician