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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is High Levels Of Liver Parameters Caused By Taking Simvastatin?

I have had an ALP test with elevated levels of 202 and a liver isoenzyme level of 17.
Could these results be related to the simvastatin that I take? This is a second ALP
taken with two days; the first resulted in a value of 195. This lead to taking the
second ALP isoenzyme test, as stated above.
Mon, 7 Apr 2014
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General & Family Physician,  's  Response
Hi,
Elevated ALP level in simvastatin treated patient are not so common but may occur in someone due to toxic intermediate of drug metabolism and reversal achieved after adaptation. This have a self limiting coarse & Idiosyncratic in nature and persistent liver injury indicate failure of adaptation process. Medication only be stopped when there is 10 fold increase in value then normal/ persistent 5 fold increase/ appearance of symptoms related to liver injury. You should take further step according to your treating physician.
Get well soon .
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Is High Levels Of Liver Parameters Caused By Taking Simvastatin?

Hi, Elevated ALP level in simvastatin treated patient are not so common but may occur in someone due to toxic intermediate of drug metabolism and reversal achieved after adaptation. This have a self limiting coarse & Idiosyncratic in nature and persistent liver injury indicate failure of adaptation process. Medication only be stopped when there is 10 fold increase in value then normal/ persistent 5 fold increase/ appearance of symptoms related to liver injury. You should take further step according to your treating physician. Get well soon .