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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Increasing Fibroid, Bleeding Out Of Control. Put Mirena, Estradol, Cramping Pain Everyday. Right Treatment ?

Need advice. I am 51 and have a 7 cm fibroid. Three years ago was diagnosed with the fibroid (3 cm then) and a small cyst on my ovary and doctor said hysterectomy was only option. Insurance called it pre-existing and to make a long story short I never had the surgery because I lost my health insurance shortly thereafter. Since 6/2010 my fibroid has more than doubled and my bleeding has been absolutely out of control with large clots. My new doctor has a totally different approach which, at first, I liked, but now I'm not so sure. She put in the Mirena iud in 6 days ago and put me on Estradiol. She said I am still ovulating and my uterine wall is extremely thick, caused by my overactive ovaries. The procedure was so painful, even with the pill to open my cervix and 4 Advil. Before the iud I had pain almost every day and now that it's in I have cramping pain every single day. Doctor said she didn't know if she could even get the iud past the fibroid, but she did. My uterine canal is so misshapen that she had to have the nurse come in and point out my uterine canal, which is pressed up against the opposite side. It says right on the pamphlet that it shouldn't be used if canal is misshapen. I am so scared of uterine perforation. And as far as the estradiol, I have an extremely high risk of breast cancer, my mother died of bc, my aunt (moms sis) died, my older sister was diagnosed 2 years ago and now my middle sister was just diagnosed 3 weeks ago. Please give me some advice because the voice in my head keeps telling me to buck up and tell the doctor to take this thing out and have the surgery.....and that little voice is usually right. Please help. Thank you.

AAAAA S
Sat, 14 Sep 2013
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OBGYN 's  Response
welcome to HCM!
a big fibroid
with excessive bleeding,
with history of cancer breast.
my advice will be-hysterectomy.
wish u all the best!
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OBGYN Dr. Bryan J Treacy MD's  Response
Thanks for your question. The presentation you describe is certainly a difficult one. The obvious answer is to have a hysterectomy for abnormal bleeding associated with the fibroid. There is a concern of malignancy in fibroids that grow rapidly, called leiomyosarcoma; yet this is a very rare form of uterine cancer.
Fibroids are estrogen dependent so giving estrogen to a woman with a fibroid can make the fibroid larger. The IUD approach is a reasonable approach. However, having an irregular cavity within the uterus makes the insertion difficult and may contribute to increased cramping. The risk of perforation is higher with a misshapen uterine cavity as you stated. A vaginal ultrasound would confirm if the IUD is in proper position and rule out perforation.
At age 51, you are close to the onset of natural menopause, which would probably alleviate the bleeding problem and the reduction in estrogen at menopause usually shrinks the fibroid.
My approach to this situation would be to perform an office hysteroscopy with visually guided endometrial biopsy to rule out cancer, polys, or precancerous growths. You don't mention if you had a biopsy after the onset of your heavier bleeding episodes. It would be a mistake to assume that the bleeding is merely from the fibroid and miss a more serious reason for the bleeding such as uterine cancer.
If visually guided biopsy is negative for cancer, there are two approaches that could be tried, with costs of each needing to be taken into account.
The least expensive option would be to place you on a high dose synthetic progestin (norethindrone acetate or medroxyprogesterone acetate) three times a day for 90 days. This is like having a continuous D&C with medication. Long acting Depo Provera injections are another possibility and not prohibitively expensive.
The most expensive approach would be Depot Lupron administration monthly. This would place you in a medically induced menopause that is reversible and is used to decrease the size of fibroids while planning removal of just the fibroid (called a myomectomy). A myomectomy is a consideration but would be just as expensive as hysterectomy so I would proceed with hysterectomy should you decide to have surgery. Lupron can reduce bone mass so a baseline bone density test is recommended followed by a post treatment bone density test. Lupron is approved for six months use by itself and for twelve months when a small dose of estrogen is given while taking this medication. The estrogen level is low enough to protect bones but not high enough to induce growth of the fibroid. Estrogen use and breast cancer risk is an entire discussion in itself, but if monitored, I believe that the benefits of estrogen treatment in menopause far outweigh the possible risks of breast cancer.
I hope this answer gives you some options to discuss with your gynecologist. However, I am available for follow up.
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Increasing Fibroid, Bleeding Out Of Control. Put Mirena, Estradol, Cramping Pain Everyday. Right Treatment ?

welcome to HCM! a big fibroid with excessive bleeding, with history of cancer breast. my advice will be-hysterectomy. wish u all the best!