Hi,Dear,Thanks for your query to HCM. Dear I read facts of your query and reviewed it in context to your health issues submitted. I understood your health concerns and feel Concerned about them. You seem to have old Pulmonary lesion-which was non-opaque in March 2011.But got calicified in few mths time. Possibility of such lesion flaring up in your case, is very high,as that lesion is still active in non-opaque area.Most commonly Pulmonary TB get reactivated in such a lesion.Such lesion could be in making in sarcoidosis / lupus lesions / or Cancerous lesions. IGRA blood test and T-spot tests give activated old calcified lesions, which could be confirmed if Sputum AFB testing is accompanied with IGRA blood test. Review of the other causes is needed for proper treatment in your case. Remedy- IN the given scenario, I would suggest you to investigate with AFB/ESR/Chest X-ray / and IGRA Blood tests- in correlation with malaise and body ache and fever with weight loss-could fix the flare up of calcified lung lesions in your case. Proper TB- DOT regimen under observation with proper follow up check up would prevent recurrence in your case. Second opinion from other Chest Specialist/ Physician would be needed. Get Second opinion with Chest Specialist/ Physician to rule out other causes as discussed above. Just don t worry and be patient and co-operate with your doctors,till you verify with your attending doctors. Hope this would help you to treat your health issues in the best way possible. Welcome for any further query in this regard to following link- http://doctor.healthcaremagic.com/Funnel?page=askDoctorDirectly&docId=70229 Wishing Good Healthy Life!! Dr.Savaskar M.N. Senior Surgical Specialist M.S.Genl-CVTS