I have several issues happening. I have an anal fissure I have been dealing with for months. I am using the ointment they gave me, doing the sitz baths, and taking stool softeners. But I have developed other problems. First it was vaginal itching that lasted for 2 weeks even after treatment from dr. for yeast infection. Now it happens randomly and makes sex impossible. The labia is what itches and the skin becomes raw and painful. I have become so scared of the itching because almost any rubbing be it toilet paper or finger seems to irritate it. This is also accompanied by the irritated skin around my anus from hemorrhoids . Its painful and itches. I also have deepening cracks in the skin in the butt crack, again painful. I have been using calmoseptine for a skin protectant but it doesn t seem to be helping the cracks heal. Hemorrhoid cream the my dr gave me helps with the anal itching but everytime I wipe irritates the skin again. It has become a mess down there. I was tested for herpes last year and have had the same partner since. My dr. tested for bacteria and yeast infection, both negative. But now I had a new symptom develop yesterday. I found blisters at the top of my butt crack. No puss, no pain, just clear fluid like a sunburn blister. I have so much going on I don t know what to do or where to focus my attention first.