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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Fluctuating Beta Levels During Early Pregnancy, Administered Methotrexate

Positive pregnancy test 3 weeks ago. My beta was only 64. Beta continues to fluctuate bw 40 and 69. 3 ultrasounds were negative for ectopic and intrauterine pregnancy. Corpus luteal cyst identified on right ovary. Methotrexate shot was administered last Friday and beta was 42. Today, 1 weeks post methotrexate, level is 67?
Tue, 18 Feb 2014
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OBGYN 's  Response
Hi,

Yours is an unusual case.
Many uncommon causes of raised beta HCG have been reported. I suggest that you first try to use another lab to test and another method. False positive rates may be due to heterophile antibodies interfering with the assay. Discuss this with your pathologist if possible.

Common causes are pregnancy, abortion, ectopic [may be ovarian pregnancy as ovary is showing a cyst that may be a sac], trophoblastic tumors [tumors of the placenta usually arise after pregnancy or abortion]

Other causes may be lung, breast, colon, kidney and many other tumors leading to similar results. A CT scan and pet scan may help in detecting these.

A diagnostic laproscopy may also help if other results are inconclusive.
Hope this satisfies your query.
Thanks for using HCM.
Feel free to ask any more questions that you may have.
Dr Madhuri Bagde
Consultant Obstetrician and Gynecologist


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Fluctuating Beta Levels During Early Pregnancy, Administered Methotrexate

Hi, Yours is an unusual case. Many uncommon causes of raised beta HCG have been reported. I suggest that you first try to use another lab to test and another method. False positive rates may be due to heterophile antibodies interfering with the assay. Discuss this with your pathologist if possible. Common causes are pregnancy, abortion, ectopic [may be ovarian pregnancy as ovary is showing a cyst that may be a sac], trophoblastic tumors [tumors of the placenta usually arise after pregnancy or abortion] Other causes may be lung, breast, colon, kidney and many other tumors leading to similar results. A CT scan and pet scan may help in detecting these. A diagnostic laproscopy may also help if other results are inconclusive. Hope this satisfies your query. Thanks for using HCM. Feel free to ask any more questions that you may have. Dr Madhuri Bagde Consultant Obstetrician and Gynecologist