Hi, Your MRI brain shows hyperintensity in flair sequences involving L) frontal and temporal lobe.Lesion is not enhancing with contrast indicates the lesion is not active Differential include gliosis from inflammation or ischemia (chronic) versus a demyelinating process. Gliosis is a nonspecific reactive change of glial cells in response to damage to the central nervous system (CNS). In most cases, gliosis involves the proliferation or hypertrophy of several different types of glial cells, including astrocytes, microglia, and oligodendrocytes. In its most extreme form, the proliferation associated with gliosis leads to the formation of a glial scar. Gliosis can occur either due to inflammation of brain secondary to infection or trauma and it can also occur following decrease blood supply to brain Other differential is demyelination .Regarding the possibillity of MS depends on the history and clinical examination and comparison with serials of MRI done previously and other tests like VEP , CSF oligoclonal band. You should consult Neurologist for further plan of action Regards Dr Sandhya Manorenj Neurologist Hi Tech city Hyderabad