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Dizziness, Fast Heart Beat, Low BP. Taking Prednisone, Methotrexate. Serotonin Syndrome?
My husband recently experienced some extreme dizziness a fast heartbeat(123) and his blood pressure was fairly low. I reviewed his medications and he is taking 25mg of amitriptyline , and 50mgs of Tramadol HCL. He also takes Prednisone amd methotrexate 2.5 mg 7 tablets. I was worried he might have Serotonin Syndrome . I was concerned about the tramadol and amitriptyline.
Fri, 11 Oct 2013
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1. Amitriptyline is TCA [tricyclic antidepressant] and tramadol is [opioid analgesic], and going through their therapeutic profile:
. Increased risk of seizures are there if both are used simultaneously.
. Increased risk of Serotonin syndrome is more with SSRI (selective serotonin reuptake inhibitors) or MAOIs (mono amine oxidase inhibitors)
2. ADR [adverse drug reaction] of both drugs when taken together or as single are: postural hypotension, dizziness, tachycardia,palpitations, [symptoms in your history]
3. There is no laboratory test for serotonin syndrome. Therefore diagnosis is by symptom observation and investigation of the patient's history, check with your Attending doctor, seek immediate medical attention.
1. Amitriptyline is TCA [tricyclic antidepressant] and tramadol is [opioid analgesic], and going through their therapeutic profile:
. Increased risk of seizures are there if both are used simultaneously.
. Increased risk of Serotonin syndrome is more with SSRI (selective serotonin reuptake inhibitors) or MAOIs (mono amine oxidase inhibitors)
2. ADR [adverse drug reaction] of both drugs when taken together or as single are: postural hypotension, dizziness, tachycardia,palpitations, [symptoms in your history]
3. There is no laboratory test for serotonin syndrome. Therefore diagnosis is by symptom observation and investigation of the patient's history, check with your Attending doctor, seek immediate medical attention.
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