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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can PSA Be Affected By Radiotherapy Or Chemotherapy?

I had non-hodgkins lymphoma recently. My PET scan in April was clear.
When I went to my GP he checked my PSA and found it jumped from .6 in 2009 to 4.4. I am going to see my oncologist first but does this ever happen because of my radiation and Chemo?
Wed, 23 May 2018
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General & Family Physician 's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

PSA is the tumor marker for prostate cancer but it is a nonspecific test. It can be raised with diseases of the prostate other than cancer. It can raise with infection or benign prostate hyperplasia. So we don't rely on its value solely, and specially if it's not very high, i.e., like yours. So I would suggest you get an ultrasound of the prostate and repeat the test after some time. You can discuss this with your doctor, if there is any suspicion on ultrasound, biopsy of the prostate can be done.

Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Mahboob Ur Rahman
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Can PSA Be Affected By Radiotherapy Or Chemotherapy?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. PSA is the tumor marker for prostate cancer but it is a nonspecific test. It can be raised with diseases of the prostate other than cancer. It can raise with infection or benign prostate hyperplasia. So we don t rely on its value solely, and specially if it s not very high, i.e., like yours. So I would suggest you get an ultrasound of the prostate and repeat the test after some time. You can discuss this with your doctor, if there is any suspicion on ultrasound, biopsy of the prostate can be done. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mahboob Ur Rahman