Sure, I was wondering if Nexium can effect your sleep patterns? I ve heard that Nexium can reduce magnesium levels in your body. From doing some research I ve found that it plays a role in sleep with melatonin. I ve been on this Rx for quite some time, seems to be the only medicine to control my acid reflux, & I ve noticed that I haven t been able to sleep well (no more than 2-4 solid hours). I haven t been able to sleep, it seems, for about as long as I ve been on this drug, Any ideas? Suggestions?