question-icon

What is the reason for elevation of thyroglobulin antibodies?

default
Posted on Fri, 2 Jan 2015
Question: What can be the reason for the elevation of thyroglobulin ab? I had papillary ca. 18 years ago (stage 1). Since then the thyroglobulin was very low. The ultrasound check I recently had showed nothing suspicious. What can cause the elevation of thyroglobulin ab? (Thyroglobulin tm was negative)
doctor
Answered by Dr. Binu Parameswaran Pillai (8 hours later)
Brief Answer:
Thyroglobulin antibody

Detailed Answer:
Good day,
Noted your concern.
Post surgery, most papillary ca need radio active iodine treatment. Later doctors monitor the disease by thyroglobulin and thyroglobulin antibody levels.
Thyroglobulin is a protein in follicular cells of thyroid. This molecule is normally protected away from exposure to our body's immune system.

When thyroglobulin is exposed to the immune system of body ( after the surgery, viral infections, radio idoine treatment etc) , antibodies are produced against it. When there is significant thyroglobulin antibody, it interferes with measurement of Thyroglobulin levels . Hence in the presence of significant thyroglobulin antibody, thyroglobulin measurement is not reliable. In this situation, We do have to do other tests like ultrasound of neck and radio idoine whole body scan to mointor. In majority of patients, this antibody will usually disappear over a period of time.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Binu Parameswaran Pillai

Endocrinologist

Practicing since :2003

Answered : 1435 Questions

premium_optimized

The User accepted the expert's answer

Share on
What is the reason for elevation of thyroglobulin antibodies?

Brief Answer: Thyroglobulin antibody Detailed Answer: Good day, Noted your concern. Post surgery, most papillary ca need radio active iodine treatment. Later doctors monitor the disease by thyroglobulin and thyroglobulin antibody levels. Thyroglobulin is a protein in follicular cells of thyroid. This molecule is normally protected away from exposure to our body's immune system. When thyroglobulin is exposed to the immune system of body ( after the surgery, viral infections, radio idoine treatment etc) , antibodies are produced against it. When there is significant thyroglobulin antibody, it interferes with measurement of Thyroglobulin levels . Hence in the presence of significant thyroglobulin antibody, thyroglobulin measurement is not reliable. In this situation, We do have to do other tests like ultrasound of neck and radio idoine whole body scan to mointor. In majority of patients, this antibody will usually disappear over a period of time.