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What is the differences between modes of Thiamine administration for Wernicke encephalopathy?

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Posted on Mon, 1 Aug 2016
Question: What are the differences between modes of thiamine administration for Wernicke encephalopathy in alcoholic patients in terms of effectiveness ?

Like orally , intravenous or intracerebral and other modes.

Which will be most effective and with what doses?
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Answered by Dr. Ashok Kumar (2 hours later)
Brief Answer:
It is intravenous

Detailed Answer:
Dear XXXXXXX
Thanks again for considering Healthcaremagic your health partner.

For a patient with significant risk of wernicke's encephalopathy intravenous thiamine should be considered for initial 3 to seven days. Since it has significant risk of allergic reaction it can be considered only in inpatient settings.

For a patient with low risk of werniicke's encpahlopathy or on outpatient treatment oral thiamin can be given.

In regard to dose, the dose is 100-300 mg per day depending on the duration alcohol intake, severity of withdrawal syndrome and many other factors. It should be continued over at least one month.

Now days benfothiamine is preferred over thiamine due to superior absorption and the dose remains same of thiamine.

I hope this helps you further.
Thanks and regards.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Ashok Kumar

Psychiatrist

Practicing since :2000

Answered : 3157 Questions

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What is the differences between modes of Thiamine administration for Wernicke encephalopathy?

Brief Answer: It is intravenous Detailed Answer: Dear XXXXXXX Thanks again for considering Healthcaremagic your health partner. For a patient with significant risk of wernicke's encephalopathy intravenous thiamine should be considered for initial 3 to seven days. Since it has significant risk of allergic reaction it can be considered only in inpatient settings. For a patient with low risk of werniicke's encpahlopathy or on outpatient treatment oral thiamin can be given. In regard to dose, the dose is 100-300 mg per day depending on the duration alcohol intake, severity of withdrawal syndrome and many other factors. It should be continued over at least one month. Now days benfothiamine is preferred over thiamine due to superior absorption and the dose remains same of thiamine. I hope this helps you further. Thanks and regards.