Brief Answer:
Irritable bowel syndrome most likely

Detailed Answer:
Hello,
Thanks for choosing HealthcareMagic for your query.
Have gone through your details and reports attached by you.
As almost all tests are the normal most likely cause in her case is Irritable bowel disease.

Firstly small briefing for Irritable bowel syndrome and why every patient is a unique case when we deal with IBS.

In IBS there is some problem in the functional ability of the gut that leads to the symptoms of irritable bowel syndrome. The structure of the intestines is normal, only functional abnormality occurs in this condition.So frankly speaking (IBS) represents a functional disorder of gastrointestinal tract without the presence of an anatomic defect.

Recent studies by French scientists have indicated that the most important mechanisms include visceral sensitivity, abnormal gut motility and autonomous nervous system dysfunction. The interactions between these three mechanisms make bowel's function susceptible to many exogenous and endogenous factors like gastrointestinal flora, feeding and psychosocial factors.

Further data indicate that according to the above mechanisms, the influence of genetic factors and polymorphisms of human DNA in the development of IBS is equally important.

So in layman's language till date, we are not sure whats the exact cause of this problem. So the million dollar question is how to repair a system when you don't know which part of it is faulty(some say it can be brain other says it can be hormone, anxiety, age etc).

Some patients have attacks of diarrhoea and bloating and some may have constipation. Other symptoms that may be present in irritable bowel syndrome include nausea, vomiting, headache, loss of appetite, muscular pains, heartburn, and weakness. Some patients have occasional symptoms whereas others may have symptoms for a long period of time.So as seen above every patient is different. The intensity of symptoms in every patient is different as so is the response to medicines and life style change.A patient may respond well to one medication while another patient is totally unresponsive to the same.

Our goal-
Every drug is not effective in every patient so we have to try different therapies till we find the drug which suits best our patient.


Dicyclomine is an anticholinergic drug.An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. Anticholinergics inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells.

Mebeverine is an antispasmodic medicine and is very useful in IBS and is well tolerated by the patient with minimal side effects.Mebeverine works on certain muscles in the wall of your intestines, causing them to relax.

Clidinium bromide is an anticholinergic (specifically a muscarinic antagonist) drug. It may help symptoms of frequent stools.

Chlordiazepoxide works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain. Can be used in combination with above-mentioned medicines.

Instead of colospa retard only, request your Gastroenterologist to prescribe her with Cibis. Cibis Tablet contains Chlordiazepoxide, Clidinium Bromide, and Dicyclomine as active ingredients. It works by relieving smooth muscle spasms of the gastrointestinal tract; calming the nerves in the brain; slowing down the natural movements of the gut as well as relaxing the muscles in the stomach.
Other than that follow all other meds as prescribed earlier by her Gastro.

Food pattern recommended is-
Give her Baill ka murabba(Ayurvedic medicine) twice daily that would help her a lot.
The isabghul husk should be taken 2 table spoon once daily before going to bed.
Eat simple and natural home cooked food.
If possible try detox diet (Raw vegans) for at least 3 months. Take normal food in lunch while in supper take the uncooked raw natural form of food. This can play wonders.

Avoid taking excessive fibres. A total fibre intake of about 20-25 gram per day would be good for her.
No pizza, Burger, Redmeat, and dairies for few weeks.

Ask her to take natural food rich in probiotics like Yoghurt, Kimchi, etc. Follow your body increase their uptake gradually.
Drink lots of juices and fresh water daily. Drink cleaner water, it will help a lot.
Avoid over spicy and heavy food.



In case you need any other help feel free to ask.I would be happy to help you.
Hope I answered your query.

Regards

---