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What Causes Joint Pains, Hair Loss, Tingling Sensation And Muscle Ache?

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Posted on Tue, 24 Jun 2014
Question: autoimmune hyperthyroidism or side effects of vyvanse?
many autoimmune disease symptoms - such as raynaud's, joint pain, occasional hair loss, tingling all over body, flu-like muscles on occasion, swollen lymph nodes from time to time (more frequently than not), insomnia, etc.
I take 60 mg vyvanse, and these symptoms have been going on for awhile. During about the middle of when my symptoms began, I was diagnosed with EBV (so I technically could have Myalgic Encephalomyelitis - but that's a last-resort diagnosis)... It's been months since the mono and my symptoms, especially the joint pain, insomnia, and hand/feet swelling, have only gotten worse.
Recently a blood test showed I have low TSH. I will go and get labs drawn to see if maybe I have autoimmune hyperthyroidism. I will also get labs for celiac and RA.
If all of that comes back inconclusive: COULD IT BE THE VYVANSE? and CAN VYVANSE USE MIMIC AN AUTOIMMUNE DISORDER AND CAUSE ASSOCIATED PROBLEMS?
could it all be Peripheral Vasculopathy (including Raynaud's, which I have) caused by the stimulant vyvanse is what I'm wondering in a nutshell.
Or is this greater than that - autoimmune perhaps? - and maybe the medication is simply exacerbating the already existing condition.
Furthermore, how does the low TSH play in. Obviously, I have yet to get any follow-up tests, though labs and tests have been scheduled. In the event that they come back inconclusive, how would the low TSH play in then?

And as for the rheumatological symptoms I've been experiencing, could those also be caused by vyvanse?

I also have occasional bloody stool and weird bowel movement (from diarrhea to constipation)

I grind my teeth (definitely from the vyvanse, I'm sure)

Furthermore, I had high (as in 80-160 mg/dL) ketones in my urine on and off for about 2 months. Currently I no longer have them, that I know of (haven't tested in awhile). I do not have diabetes... this is yet another confounding variable that confuses any logical diagnosis.

And lastly - my liver enzymes came back slightly, slightly elevated at 43 on a range of 0-40. Since it's only just outside of range I don not think it should be worrisome, but I am not sure what could be causing this as I only rarely drink anymore, and I only just recently (as in within the last two days) started taking my ambien to sleep again) - at the time of the blood test I was not taking sleeping medication. Should this be a concern?
doctor
Answered by Dr. T Shobha Deepak (10 hours later)
Brief Answer:
To rule out Idiopathic Thrombocytopenic Purpura

Detailed Answer:
Hi
Welcome to Healthcare-Magic
Greetings of the day
Dear Ms XXXXXXX

1.Vyvanse (lisdexamfetamine dimesylate) is a amphetamine group of drug which is symphatomimetic drug useful in management of ADHD. It is unlikely to be culprit in causation of any of the symptoms mentioned above by you. One of the side effects of this drug is Insomnia.

2. Low TSH is likely to be due to Hyperthyroidism: Presence of circulating high levels of Thyroid hormone ( T3 and T4) will suprss release of TSH fro Pituatory gland local in brain causing lowered TSH levels. This is also unlikely to be related to Vyvanse intake.
It will require further assessment by
1. Serum T3, T$ and TSH levels
2. Ultrasound of Thyroid



From the clinical photograph provided by you, there appears to be pupuric rash ( usually due to bleeding in the blood vessel of the skin) which is more likely if the rash still remains red even on applying skin pressure.
From the descrition provided by you, one of the differential diagnosis I would strongly consider and rule out is " Idiopathic Thrombocytopenic Purpura (ITP).

Presence of following things suggest the possibility.
1. Gastro-intestinal involvement: Bleeding in stools
2. Skin rash
3. Joint involvement

I would suggest you to discuss this probability with your treating Physician.

Do keep me updated about the developments. Kindly let me know if you need any further clarification.

Take Care

Best Regards
Dr T Shobha Deepak
MBBS,MD

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. T Shobha Deepak

General & Family Physician

Practicing since :2005

Answered : 1774 Questions

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What Causes Joint Pains, Hair Loss, Tingling Sensation And Muscle Ache?

Brief Answer: To rule out Idiopathic Thrombocytopenic Purpura Detailed Answer: Hi Welcome to Healthcare-Magic Greetings of the day Dear Ms XXXXXXX 1.Vyvanse (lisdexamfetamine dimesylate) is a amphetamine group of drug which is symphatomimetic drug useful in management of ADHD. It is unlikely to be culprit in causation of any of the symptoms mentioned above by you. One of the side effects of this drug is Insomnia. 2. Low TSH is likely to be due to Hyperthyroidism: Presence of circulating high levels of Thyroid hormone ( T3 and T4) will suprss release of TSH fro Pituatory gland local in brain causing lowered TSH levels. This is also unlikely to be related to Vyvanse intake. It will require further assessment by 1. Serum T3, T$ and TSH levels 2. Ultrasound of Thyroid From the clinical photograph provided by you, there appears to be pupuric rash ( usually due to bleeding in the blood vessel of the skin) which is more likely if the rash still remains red even on applying skin pressure. From the descrition provided by you, one of the differential diagnosis I would strongly consider and rule out is " Idiopathic Thrombocytopenic Purpura (ITP). Presence of following things suggest the possibility. 1. Gastro-intestinal involvement: Bleeding in stools 2. Skin rash 3. Joint involvement I would suggest you to discuss this probability with your treating Physician. Do keep me updated about the developments. Kindly let me know if you need any further clarification. Take Care Best Regards Dr T Shobha Deepak MBBS,MD