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What Causes Body Pains, Muscle Wasting And Nerve Weakness?

Posted on Tue, 3 Jun 2014

Question: Pain in whole body nrvs Wkns Muscles waisting Mnd diagnos by many dr's.. I hd snd u my reports.. plz tell me.. Nd i had taken stem cell therapy in this feb Bt weakness is increasing.. also muscles waisting increasd Its too much paining in both under arms...

Mnd
Motor neurone diseas..
Mncv ??
Not confirmed yet

Answered by Dr. Sudhir Kumar (4 hours later)

Brief Answer:
MND is less likely.

Detailed Answer:
Hi XXXXXXX ,

Thank you for posting your query.

I have gone through the medical reports sent by you.

I agree that the doctors have suspected/made a diagnosis of motor neuron disease (MND) in your case.

However, it is less likely. This is because MND is very unusual at this young age. It typically occurs in people above 50.

Secondly, too much pain in muscles is not a feature of MND.

Thirdly, the progression is relatively slower for MND. In a typical person with MND, the disease spreads to legs and swallowing/speaking muscles in 3-5 years.

The more likely possibilities could be multifocal motor neuropathy with conduction block (MMNCB), and segmental anterior horn cell disease. Both these conditions have better outcomes than MND.

MMNCB responds to treatment with immunotherapy (cyclophosphamide, immunoglobulins, etc).

I hope my reply has helped you.

I would be pleased to answer, if you have any follow up queries or if you require any further information.

Best wishes,
Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) XXXXXXX Consultant Neurologist
Apollo Hospitals, XXXXXXX
For DIRECT QUERY to me: http://bit.ly/Dr-Sudhir-kumar
My blog: http://bestneurodoctor.blogspot.com/

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Sudhir Kumar (4 hours later)

Hello sir,
I agree with ur answers
Bt sir
Jaw pain md muscles waisting nd weakness is symptoms of mnd...
Nd as i read on the internet for mnd
Its not confirmed age
Its varified to symptoms.
I had met with u since 2011
Nd that tym u had diagnsd mmncb
Nd suggest me for nerves biopsy
Then i had gone banglore nimhans for nerves biopsy
There,s dr had diagnsd mnd..
I feel my left leg nd whole left side area is very weak including my leg
In that tym i m suffering from breathlessness.plzz tell me sir what's d actual nd correct diseas
Actuly i get very frusted from whole prblms nd various diagnosis..

Answered by Dr. Sudhir Kumar (26 minutes later)

Brief Answer:
You need to have positive outlook.

Detailed Answer:
Thank you for getting back.

I can understand your frustration with lack of confirmed diagnosis and lack of any definite treatment so far.

Motor neurone disease is not a uniform disease, and the severity and progression may differ in different individuals.

As of now, I would expect you to continue with your current neurologist's advice.

In addition, you should have a positive outlook and do regular exercises.

Best wishes,
Dr Sudhir Kumar MD DM (Neurology)

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Sudhir Kumar (16 minutes later)

Its continuing physiotheraphy nd xrcises
Nd neurologist had told me that only riluzole drug for me
Sir plzz tellle ur advice..
Do we stop or stay my problem in this stage.
Nd what i do for No progression..
Isn't any other option nd no other treatment for me..
Thanx to understanding my frustation
Sir...

Answered by Dr. Sudhir Kumar (9 minutes later)

Brief Answer:
Continue physiotherapy and riluzole.

Detailed Answer:
Thank you for getting back.

You should continue physiotherapy and exercises.

Riluzole is a good drug to stop/delay the progression of MND.

If you still progress, you can take a course of immunotherapy (with medications such as cyclophosphamide or IVIG, etc).

Best wishes,
Dr Sudhir Kumar MD DM (Neurology)

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar