Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

192 Doctors Online
Doctor Image
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

What are the chances of pregnancy naturally after completing 6 months of TB medication?

Answered by
Dr. Mahesh Koregol

Infertility Specialist

Practicing since :2000

Answered : 3768 Questions

Posted on Wed, 27 Aug 2014 in Infertility Problem
Question: I had 1 laparoscopy to remove blood cyst or endometriosis of Grade IV (CA 125 SERUM - 81.28*)
And 5 IUI in one year, and ICSI - Day 3 embryo transfer (3 embryos transferred -10 cell grade 1, 10 cell grade 2, 6 cell grade 2 (compaction)) in April 2014 with Frozen Sperm which is failed
And my doctor advising me to go for another IVF/ICSI with Day 5 blastocyst.
She said that she is going to do same procedure but asking me not to keep any hopes at all. Somehow, I felt that she is not trying to know the root cause of failure. And she is assuming it is an implantation failure because of endometriosis disease.
I approached another doctor in May 2014; she did all types of tests again.
Test Results:
ANA (Anti-Nuclear Antibodies) - NEGATIVE
Cytogenetic Report: Karyotype: 46, XX, karyotype using peripheral blood.
AMH - 6.29, FSH: 3.26
And while doing follicular study scans, there is some pain on left ovary side. Endometriosis is slowly growing on that side which is at grade 1.
Then doctor suggested me to get uterus biopsy done using endometrial tissue.
Before the endometrial tissue removal, some injection was given for which I felt very thirsty and I don't remember the injection name.
Result of Endometrial Tissue examination is POSITIVE.

MTBC - Mycobacterium tuberculosis complex - POSITIVE
TNF - Tumor Necrosis Factor activity - POSITIVE
NK - Natural Killer Cells activity - (25-60%) HIGH POSITIVE

With this report, they have sent me to another doctor who treats for Uterus Tuberculosis. And the doctor didn't give me chance to talk about the disease and severity of it. He suggested using Monto-4 (post 2 hours of breakfast) every day.
I did lot of browsing to know about the disease and understood some points as these medicines can impact on Liver, and I shouldn't miss at least 1 day and should maintain the exact timings etc.,
At present, my husband & I are not in relation since 5 months, he has gone abroad.

My Questions & Concerns are:
1. Am I going in right direction in taking medication or treatment?
2. Are there any chances of getting pregnancy naturally after completing 6 months of TB medication? Can I make plans to go to my husband's place and try for natural pregnancy after or during this medication?
3. I read that there are more chances of miscarriages if someone gets pregnancy during TB medication. Is it true? If yes, shall I wait for 6 months without meeting him?
4. Once TB medication is over, what is the next step in increasing the chances of getting pregnancy?

None of the doctors are giving me at least 5 mins of their time to talk with personal care, or not explaining the actual problems or what the next steps are. I browse over the internet with the test reports and try to understand the things.
1st Doctor didn't give at least a small hint about the side effects of using steroids are used for implantation support during IVF cycle. She just asked me to stop all medicines after failure. I have suffered with side effects and didn't realize for couple of days and later understood that it is because of stopping steroids suddenly. I am not getting a chance to talk properly to any doctors as we approach famous doctors in city and they would be busy in treating maximum number of patients in their day time. And my 1st doctor didn't even recognized my face just after 5 mins of IUI procedure, and she is asking me when did I do IUI for you when am asking some question related to post medication? And my thyroid levels never tested before IVF cycle. All the 5 IUI's are useless as they did without detecting thyroid problem which is at (6.17)

So, I fed up with all these experiences and my hopes are going down day by day.

Please Please Please advise me doctor what should i do now?
Answered by Dr. Mahesh Koregol 6 hours later
Brief Answer:

Detailed Answer:

I read your query and I understand your concerns.

Following is my reply

1. Endometriosis also decrease oocytes quality. Hence you embryo won't be very good.

2. The tuberculosis causes damage to endometrium and hence implantation is difficult. You are in right direction about taking medicines. Please complete course

3. There could be adenomyosis of uterus associated as you have grade 4 endometriosis. This could have lead to implantation failure.

4. Considering your age and history of tuberculosis natural conception is little difficult.

5. You can keep trying with husband naturally while you are on medicines. Atleat it will confirm if you can conceive naturally.

6. Miscarriage chances though exists it is still a chance and you should take a chance to make sure you can get pregnant as tuberculosis destroys endometrium.

7. I am sorry with your bad experiences with doctors. Let me know which city you are living and which doctor you have seen. I can suggest a different and credible doctor.

Let me know the details.


Dr. Mahesh Koregol

ICE & Infertility Specialist.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
Follow up: Dr. Mahesh Koregol 20 hours later
Thanks for the detailed answers doctor.

1. I had IUI , IVF procedures in Rainbow Hospitals, XXXXXXX
2. Had endometrial biopsy test in IIRC, Secunderabad.
3. TB medication by XXXXXXX sunder , Family Clinic - bowenpally , Secunderabad.

I heard that IIRC is the top infertility hospital in XXXXXXX But doctor mamatha gives her appointment only for the first time. Different doctor for every subsequent visits who will just explain the prescription after the ultrasound scan. There is no prior appointment and my token number would be 190+ always even i reach the hospital at 7:00 AM. Scan for 5 mins and explaining prescription in 5 mins.But waiting time is almost 6 hrs of the day.

But, luckily IIRC suggested me go for endometrial biopsy test to know the root cause before proceeding for any other IVF. But they didn't tell what the next steps are? could be because I should complete ATT before anything else.

But , I expect someone who shows little more personal care , little more explanation of the disease am having now, and give accurate information about the next steps etc.,

Answered by Dr. Mahesh Koregol 4 hours later
Brief Answer:
Next step

Detailed Answer:

The next step would be as follows

1. Complete the tuberculosis medicines course.

2. Repeat the endometrial biopsy test to make sure there is no tuberculosis.

3. Go for another cycle of IVF.

I hope your doubt is cleared.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions ,   ,  
Medical Procedures ,  
Medical Topics

Recent questions on  Mycobacterium tuberculosis complex

doctor1 MD

My FNAC of Right Cervical Lymph Node, Received 3 fixed unstained smears. Microscopic study says "Sparsely Cellular Smears show heterogenous population of reactive lymphocytes". "Granulomas are not seen". FNAC of Cervical Lymph Node for Gram Stain...

doctor1 MD

My father aged 74yrs and weighs 46kgs tested AFB positive in sputum. After taking AKURIT 4 (3 tabs) for two months and RCINEX(300+ 450) for four months he was tested negative for AFB. But after eight months he was again tested AFB positive. HE was...

doctor1 MD

Hai, kindly request you to suggest the necessary preliminary tests to make sure everything in reproductive organ is good piror to start IVF treatment for my wife. My wife showing PCOD during scan with normal 30 days menstrual cycle and AMH is...

doctor1 MD

My wife 27 yrs old 57kg & 5.4ft is suffering from Mycobacterium tuberculosis complex in menstrual blood. Is it communicable ? Is this a reason for not conceived yet ? Dr. prescribed TAB AKT 4, Zanocim 200mg and Dupheston 10mg. What is your comment on these medicines ?

doctor1 MD

Do I have Uterus tuberculosis ? My Uterus Lining is very thick.

During Follicular Monitoring,endometrium was found abnormally thick. Like 8 mm on Cycle Day 3. It kept growing to 22 mm during ovulation period. OB did Hysteroscopy to rule out septate. While D&C, they sent the sample for Endometrial Biopsy. Report says: Proliferative endometrium with Chronic Endometritis. PCR says...
Microscopic Examination:
Sections show multiple endometrial tissue fragments comprised of tubular proliferative glands with compact sorrounding Stroma. However the Stroma shows fibroblastic alteration with miild to moderate increase in chronic infilterate

Not Detected both Mycobacterium tuberculosis complex and Non Tuberculous Mycobacteria.. Doc is suggesting for TB Course..