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Suggest Medicines That Are Affected By Drinking Grape Juice

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Posted on Wed, 25 Jun 2014
Question: ARE ANY OF THESE MEDICINES Affected by eATING OR DRINKING GRAPEFRUIT JUICE? SERTRALINE, LEVOTHYROXINR\E, SIMVASTATIN, DIGHOXOINE
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Answered by Dr. Dr. Ivan Romich (30 minutes later)
Brief Answer:
hi and welcome to hcm.

Detailed Answer:
Thanks fir the query.
Yes, simvastatin,levotiroxine and sertraline are affected by grapefruit since these drugs are metabolised by citocrom oxidase in liver. grapefruit will inhibit this enzyme so concentration of these drugs in blood will be affected too. however it shouldnt cause serious side effects,but it will reduce drugs efficiency. Since you take 3 drugs i suggest not to intake grapefruit. Wish you good health. Regards
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Dr. Ivan Romich

General Surgeon

Practicing since :2008

Answered : 13888 Questions

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Suggest Medicines That Are Affected By Drinking Grape Juice

Brief Answer: hi and welcome to hcm. Detailed Answer: Thanks fir the query. Yes, simvastatin,levotiroxine and sertraline are affected by grapefruit since these drugs are metabolised by citocrom oxidase in liver. grapefruit will inhibit this enzyme so concentration of these drugs in blood will be affected too. however it shouldnt cause serious side effects,but it will reduce drugs efficiency. Since you take 3 drugs i suggest not to intake grapefruit. Wish you good health. Regards