question-icon

Should dosage of Anastrozole be increased to regulate estradiol levels during testosterone therapy?

default
Posted on Wed, 20 Sep 2017
Question: I am on testosterne theropy. I am only injecting .05 cc twice a week of testosterone. I am also taking 50 mg of Oxandrolone per day. I keep trying ti see why my E2 levels are raising. I tried to take 0.5 mg of anastrzole Twice a week and still remained high. I dont want to take too much and kill all levels what is suggested amount ir reccomendation
doctor
Answered by Dr. Mirjeta Guni (13 hours later)
Brief Answer:
About testosterone and anastrazole therapy:

Detailed Answer:
Hello and thank you for asking!
Most men think of estrogen as exclusively a female hormone, but men also produce it.
In fact, testosterone is the precursor of estradiol, an estrogen and the primary female sex hormone. Testosterone is converted into estradiol via the aromatase enzyme.
Because testosterone can be converted into estradiol, taking testosterone via testosterone replacement therapy (TRT) can potentially elevate estrogen levels.
While there is currently not enough data and/or information to know what is the optimal estradiol range in men, low estradiol levels are evidently not good.
As such, taking anastrozole in the absence of clinically diagnosed high estradiol levels along with associated symptoms (gynecomastia and edema) is likely counterproductive for men on testosterone therapy.
So, only high estradiol levels (without clinical symptoms) is not a sufficient data to judge about anastrazole treatment and it's dose.
Hope i have been helpful and clear.

Best wishes,
Dr.Mirjeta
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
Answered by
Dr.
Dr. Mirjeta Guni

Endocrinologist

Practicing since :2006

Answered : 2414 Questions

premium_optimized

The User accepted the expert's answer

Share on
Should dosage of Anastrozole be increased to regulate estradiol levels during testosterone therapy?

Brief Answer: About testosterone and anastrazole therapy: Detailed Answer: Hello and thank you for asking! Most men think of estrogen as exclusively a female hormone, but men also produce it. In fact, testosterone is the precursor of estradiol, an estrogen and the primary female sex hormone. Testosterone is converted into estradiol via the aromatase enzyme. Because testosterone can be converted into estradiol, taking testosterone via testosterone replacement therapy (TRT) can potentially elevate estrogen levels. While there is currently not enough data and/or information to know what is the optimal estradiol range in men, low estradiol levels are evidently not good. As such, taking anastrozole in the absence of clinically diagnosed high estradiol levels along with associated symptoms (gynecomastia and edema) is likely counterproductive for men on testosterone therapy. So, only high estradiol levels (without clinical symptoms) is not a sufficient data to judge about anastrazole treatment and it's dose. Hope i have been helpful and clear. Best wishes, Dr.Mirjeta