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Is High MCV Level In A Blood Test Unusual?

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Posted on Thu, 24 Mar 2022
Question: i have hight lab tests
Is high MCV level in a blood test unusual?
doctor
Answered by Dr. Panagiotis Zografakis (37 minutes later)
Brief Answer:
Polycythemia?

Detailed Answer:

Hello,

The main problem with your test is the high hematocrit. 61.7% is too high and usually occurs in polycythemia vera. Your MCV is high as well. In polycythemia the MCV is low in most cases due to lack of the required iron. A high MCV may be the result of a co-existing disorder, that can't be determined with the current data.

If you already have a diagnosis or have done more tests please let me know (and upload the relevant information).

I hope I've answered your query! Let me know if you need further assistance.
Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Panagiotis Zografakis (11 minutes later)
i have few other results..ut the system is not allowing me.. ill try again
doctor
Answered by Dr. Panagiotis Zografakis (19 minutes later)
Brief Answer:
I've checked 7204, 4076 and 7301

Detailed Answer:

Hi,

I've checked some of them and they're not adding much (useful) information. When we find a very high hematocrit we first try to exclude secondary causes like serious lung disease for example. More detailed testing is also indicated. An ultrasound scan of the abdomen (searching for enlarged liver and spleen) would be helpful.
If the secondary causes are not very likely then bone marrow testing will be required.

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Panagiotis Zografakis (16 minutes later)
okkk..
i always do check ups from now and then.. n they r always like that..plus or minus..
always had the high hemoglobin, uric acid, LDL.. sometimes the creatinine ..
and is the slightly high SGPT indicate any thing..
and i have hypothyroidism
i've uploaded the final tests i made
n.b. i lived in a high sea level almost 3km from 10 years back for 5 years
doctor
Answered by Dr. Panagiotis Zografakis (9 hours later)
Brief Answer:
The high altitude may contribute to the high hematocrit

Detailed Answer:

Hi,

The high altitude definitely contributes to the high hematocrit but any hemoglobin level higher than 18,5 is worth investigating (it's a major criterion for polycythemia). Despite that and taking into account your age as well (polycythemia is very rare in individuals of your age) perhaps the local doctors may be more accustomed to the high hematocrits.

There is no strict rule for how high the hematocrit can go with high altitudes but yours is definitely high. If 1 out of 10 individuals living in your area have 61% then perhaps this hematocrit wouldn't sound that alarming any more. Your doctor can help you with that.

Regarding the rest of the tests:
- The high SGPT is not very worrisome. It may indicate disorders but the most likely cause is fatty liver disease which is an accumulation of fat in the liver due to increased body weight, alcohol consumption or diabetes (or all of them!). If none of them applies to you then you should be tested for various types of hepatitis (mostly B, C and autoimmune hepatitis). Follow-up testing might be helpful in some cases.

In fatty liver disease we usually find the same values all the time unless the patient's body weight changes. In chronic hepatitis the levels may fluctuate. Other less common disorders can be investigated as well but only if the first basic investigation is negative and there is still suspicion that something is wrong. Another common cause that can't be 'diagnosed' without excluding all the other potential causes is a side effect of commonly used drugs like painkillers, antibiotics, etc.

- Your lipid profile is not perfect but it's not very worrisome either. It would have been better if your LDL was a little lower and you can help it get to lower levels by stopping smoking (if you smoke!), eating more vegetables and fruits and less red meat. Fish can be consumed even every day if you like. If you have (or develop) diabetes mellitus then treatment for your cholesterol would become necessary with its current levels.

- Your thyroid testing is borderline normal. Repeat testing is indicated perhaps also with anti-thyroid antibodies looking for Hashimoto's thyroiditis. An ultrasound scan of the thyroid might provide additional information (the presence of 'abnormal' thyroid tissue as in thyroiditis or the presence of nodules).

- Your creatinine levels are higher than normal. If you're indeed overweight then this might partly explain it but 1,6 is still high. In such cases we have to compare this value to values of previous tests. If you had 1,0 for example then 1,6 might indicate renal damage.

- The potassium levels are a little on the high side although not high enough to cause any immediate concerns. Since potassium measurements are frequently affected by the blood-drawing technique a repeat measurement is indicated.

- The high uric acid might concern as only when it's too high (like 12 or 13) or when a patient has a history of gout, uric stones in the kidneys or skin nodules caused by uric acid. If you have none of the above then this is not very worrisome but it does mean that your metabolism is not in great shape.

Increased waist perimeter, glucose control disorders, unfavorable lipid profile, high uric acid and sometimes high blood pressure are commonly associated disorders (metabolic syndrome). Loosing weight and increasing your physical activity is the right way to go. This - obviously - applies to overweight or obese individuals!

Please let me know if you need more info on any of the above! At first I thought you were concerned about the hematocrit only!
Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3809 Questions

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Is High MCV Level In A Blood Test Unusual?

Brief Answer: Polycythemia? Detailed Answer: Hello, The main problem with your test is the high hematocrit. 61.7% is too high and usually occurs in polycythemia vera. Your MCV is high as well. In polycythemia the MCV is low in most cases due to lack of the required iron. A high MCV may be the result of a co-existing disorder, that can't be determined with the current data. If you already have a diagnosis or have done more tests please let me know (and upload the relevant information). I hope I've answered your query! Let me know if you need further assistance. Regards