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Do Efavirenz And Tenofovir Decrease The Effectiveness Of Regestrone?
Question: Hi,
I am taking regestrone 5mg twice a day to delay my periods for a week. But I am on efavirenz and Tenofovir so do I need to increase the dose of regestrone as efavirenz and Tenofovir decrease regestrone levels in blood.
Thanks.
I am taking regestrone 5mg twice a day to delay my periods for a week. But I am on efavirenz and Tenofovir so do I need to increase the dose of regestrone as efavirenz and Tenofovir decrease regestrone levels in blood.
Thanks.
Brief Answer:
Dose adjustment recommended
Detailed Answer:
Hi,
Thanks for asking on HealthcareMagic.
Regestrone contains norethisterone which is basically a low dose oestrogen. Enzyme inducers like efavirenz and tenofovir may reduce the blood levels of such medicines by 40-75 %. So, dose adjustment is preferable. Ideally double the dose would be reasonable, but please go for dose adjustment only under the guidance of your treating physician.
Regards,
Dose adjustment recommended
Detailed Answer:
Hi,
Thanks for asking on HealthcareMagic.
Regestrone contains norethisterone which is basically a low dose oestrogen. Enzyme inducers like efavirenz and tenofovir may reduce the blood levels of such medicines by 40-75 %. So, dose adjustment is preferable. Ideally double the dose would be reasonable, but please go for dose adjustment only under the guidance of your treating physician.
Regards,
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by :
Dr. Raju A.T
Answered by
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