Can Propofol be effective during surgery on a person who smokes Marijuana?
My question is since she has being smoking pot for here pain can the propanol be less effective?
first, you don't mean heart drug propranolol but sedative propofol
This just isn't an effect that is seen. There are a LOT of other medications and conditions that could. There are two mechanisms that can do this...amount of drug and sensitivity to drug.
amount of drug can be affected by things that alter liver metabolism of drug these include other drugs, illnesses such as the flu, herbal supplements and even grilling food (increases drug metabolism). Smoking might do a bit of this. Pot smoking, probalby NOT.
Pediatric populations are notoriously difficult to dose with this drug and they metabolize it faster than adults.
The effect of the drug can be affected by things that change the activity of the brain. Nervousness for example can lower it's effectiveness. Getting used to sedation due to frequently being sedated. The presence of other drugs can make it more effective (other sedatives). Metabolic problems like low sodium will affect the drug's ability to function. Pot on board would likely make it more effective; if someone had pot withdrawal enough to be anxious or worse then that could interfere wtih sedation.
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