HealthCareMagic is now Ask A Doctor - 24x7 | https://www.askadoctor24x7.com

Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
159 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

Started Terbinafine For Tor Nail Fungus, Nerve Damage In Lower Legs And Feet. Pain, Fatigue, On Lortab, Klonipin. Is That The Cause ?

i started terbinafine for a tornail fungus 5 days ago. I have had nerve damage in my lower les and feet for 7 years from a back surgery that went terribly wrong.
so I experiance some pain and fatigue from and have been on 10/500 lortab and klonipin for several years. The last 3 days I have more fatigue and pain than usual and in my joints my arms , hands,and legs. I've tried to go to bed and sleeo but the aching is terrible. Could this new drug be the cause?
Wed, 21 Aug 2013
Report Abuse
General & Family Physician,  's  Response
Hi,

It is possible that the new drug terbinafine is creating the issue.

Potential drug interactions that could reduce efficacy or drug toxicity must be taken into account when assessing the benefits and risks of the different oral antifungal agents. The most common hepatic enzyme involved in drug metabolism is cytochrome 3A4 (CYP3A4), which is required for the clearance of many different therapeutic agents.

In short it act with enzymes from liver which normally act on drugs to remove it, but due to terbinafine it may prolong the drugs metabolism creating various side effects.

Thanks for the query.
Hope it helps.
Dr.JAY PATEL.
I find this answer helpful
Note: For further queries, consult a joint and bone specialist, an Orthopaedic surgeon. Book a Call now.
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]
Share on
 

Recent questions on Terbinafine


Loading Online Doctors....
Started Terbinafine For Tor Nail Fungus, Nerve Damage In Lower Legs And Feet. Pain, Fatigue, On Lortab, Klonipin. Is That The Cause ?

Hi, It is possible that the new drug terbinafine is creating the issue. Potential drug interactions that could reduce efficacy or drug toxicity must be taken into account when assessing the benefits and risks of the different oral antifungal agents. The most common hepatic enzyme involved in drug metabolism is cytochrome 3A4 (CYP3A4), which is required for the clearance of many different therapeutic agents. In short it act with enzymes from liver which normally act on drugs to remove it, but due to terbinafine it may prolong the drugs metabolism creating various side effects. Thanks for the query. Hope it helps. Dr.JAY PATEL.