Are these synthetic hormones safe to take?
I am 26 years old and had amennorhea, trying to concieve, was given meprate to induce bleeding and clomid 100 mg from CD 2 to CD 6.
I ovulated on 22nd April, dr adviced to start Duphaston 10 mg bid for 20 days till I take pregnancy test.
My question is, though my ET is 9.7, should i still take duphaston? Are these synthetic hormones safe? I have not had any miscarriages.
Side effects are not common, so you may opt it.
Welcome to HCM. I have gone through the question and understand your concerns.
Most gynaecologist prefer to give Duphaston as a protection to early gestation to decrease the risk of abortions especially if you have conceived after ovulation induction ( clomid) .
These synthetic hormones are associated with side effects. Major ones are like 1 in 10,000. It is a category B drug in pregnancy - relatively safe and benefits are more than risks.
There are controversial benefits of progesterone in preventing miscarriages and preterm delivery. So it's usually recommended when you have a risk of miscarriage. If you don't have (as in your case ) you can choose for or against it.
Hope I have answered your questions. If you have any further queries I will be happy to help you.
Dr Ajish TP [MD,DM]
Also, last year when my TSH was checked it was 4.18, t3, t4, free t3,free t4, anti tpo antibodies everything was normal.
My gynaec suggested I start thyronorm 25mcg,
Was confused, hence went to a endocrinologist for 2nd opinion, he said to start 50 mcg thyronorm.
Then now my TSH is 2.24.. Should I continue 50 mcg or come down to 25 mcg?
You need to continue with 50 mcg
Hi Mrs XXXXXXX
Hypothyroidism even if mild, is associated with increased risk for abortion. So we tend to over treat hypothyroidism in pregnancy. Thyronorm is a safe medication in pregnancy.
The target TSH in pregnancy is less than 2.5 miu/ml. We have to take the thyronorm dose to keep the TSH below this level. Since your TSH is 2.2 on thyronorm 50 mcg, you are now appropriately replaced and need to continue the same dose of medication.
You need to do the TSH and total T4 every month in pregnancy to adjust the thyronorm dose.
Hope I have answered your question
Dr Ajish TP
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