Brief Answer: des-venlafaxine is antidepressant of choice Detailed Answer: Hi Thanks for using healthcare magic. I, Dr Abhishek Kapoor, would help you in this query. All antidepressants help in increasing serotonin level and dopamine level, thus help in decreasing depressive symptoms. Response with antidepressant varies patient to patient and its use depend upon clinical experience of physician or psychiatrist. If you are not getting any effective with prozac (fluoxetine), then you can try des-venlafaxine or paroxetine. Desvenlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor and effective in peri-menopausal female. It has very less side effects and would not aggravate diabetes or hypertension. Paroxetine is an antidepressant of selective serotonin uptake inhibitor and effective in controlling depressive symptoms. Both these antidepressant are very effective and you can choose either one. Rest you can discuss with your psychiatrist or physician. In case, you need further help, you can ask. Regards Dr. Abhishek Kapoor Psychiatrist

---

Brief Answer: Duloxetine has good effect on somatic symptoms Detailed Answer: HI Cymbalta consists of duloxetine and it is a antidepressant of the serotonin-norepinephrine reuptake inhibitor, but it has good response on somatic symptoms rather than depressive. You can choose either duloxetine or desvenlafaxine because both are from same group. In the beginning of treatment, no one can say how drug would response. So, you can take cymbalta if you want and hope that it would work. Rest choice would be yours. In case, you need further help, you can ask. Regards Dr. Abhishek Kapoor Psychiatrist

---