Hi, There is a potential for drug interactions between Prozac (fluoxetine) and Wellbutrin (bupropion) when taken together, which may increase the risk of seizures. Marijuana use may also increase the risk of seizures. Both Prozac and Wellbutrin can lower the seizure threshold, meaning they can make it easier for seizures to occur. This risk may be increased when the two medications are taken together. Marijuana use can also lower the seizure threshold and may further increase the risk of seizures. Additionally, it is worth noting that while some people may find that marijuana use helps with their symptoms, it is not a recommended treatment for depression or anxiety. There are other effective treatments available that do not carry the same potential risks as marijuana use. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Diwashish Biswas, Internal Medicine Specialist