Hi,
Thanks for asking in Healthcare Magic.

Both Diltiazem and Amlodipine (Lotrel) are calcium channel antagonists. Metaprolol is a beta blocker. All three drugs reduce heart rate and are mainly used in the treatment of hypertension, angina and arrhythmia and each drug has its own unique action.

As calcium channel blockers, Amlodipine and Diltiazem reduces the heart rate, reduce myocardial contractility and work load of heart. They also cause relaxation of blood vessels and reduce BP, reduce venous return to heart leading to reduced end diastolic volume and work load of heart. But, Amlodipine has more action on blood vessels than on heart, Diltiazem has equal action on heart and blood vessels. Amlodipine has long duration of action.

Metoprolol mainly acts on heart and reduces the heart rate and force of contraction of heart. All three drugs act on sinoatrial node (SA), the pace maker of heart and reduce the impulses generated by SA node resulting in reduced heart rate. That's why your heart rate is at 90.

Beta receptors present in SA node are directly inhibited by Metoprolol as it is a beta blocker. So your heart rate reduced to 60 and subsequently has come back to normal due to hemodynamic responses.

Metoprolol reduces the heart rate and contractility to reduce oxygen consumption particularly during exertion or exercise as a protective measure. It is due to Metaprolol your heart rate is reduced to 60 during exertion and there is nothing to worry about it since it comes back to the original rate.

Nausea could be due to orthostatic hypotension (sudden fall in BP) during exercise. Orthostatic hypotension results in reflex tachycardia and increases the heart rate as a compensatory measure. You should discuss this issue with your treating Dr if nausea becomes too troublesome and severe.

I hope this helps. Please address to me if you have any other concerns.
Regards.

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Hi.
Welcome back to the Forum.

I would like to clarify certain aspects about Metoprolol. Oxygen consumption by heart is directly proportional to the amount of work done by heart. Whenever the heart contracts, it needs energy for contraction and utilizes oxygen as a source of energy. The higher the force of contraction, the greater will be the work done by heart and so the oxygen utilization (consumption) by heart will be more. So, what we mean by oxygen consumption is the work load of heart.

During exercise, the heart works more. The heart rate and force of contraction are increased during exercise. This will add up to the strain, in an already compromised heart. Metoprolol reduces this strain by reducing the work load of heart. Reduced oxygen consumption by Metoprolol means, reduced heart rate, force of contraction and work load of heart.

This is a protective effect (therapeutic benefit) of Metoprolol and sorry for not explaining it clearly earlier. Also, this action of Metoprolol is more when the heart exerts like during exercise and not seen at rest (when the heart beats normally), an additional benefit. And more importantly, Metoprolol should not be stopped suddenly and can only be tapered slowly. These three drugs are beneficial in your condition and are favourable drug combinations. They are not harmful to you.

I feel, the nausea and fatigue during exercise may either be due to over exertion of heart or may be due to sudden fall in BP. Vigorous exercises are not indicated in cardiac problem and you should really discuss with your treating Dr about the type of exercises you can do. Regular walk is an easy and time tested method of reducing weight and this will not strain the heart.

I hope I am more clear this time. Please feel free to contact me if you have any further queries.
Warm regards.

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