Hi, Depo-medroxyprogesterone acetate (DMPA) injection is a form of hormonal birth control that is administered every 12-14 weeks. While it is generally a safe and effective contraceptive method, some women may experience side effects such as weight gain. Weight gain is a common side effect of DMPA use and can be due to a variety of factors such as increased appetite, fluid retention, and changes in metabolism. However, weight gain is not experienced by all women who use DMPA and the amount of weight gained varies from person to person. In addition to weight gain, other side effects of DMPA injection may include irregular menstrual bleeding, headache, dizziness, breast tenderness, mood changes, and decreased bone density over time. It is important to discuss any concerns or side effects with your healthcare provider to determine if the benefits of the medication outweigh the risks. If you are experiencing tiredness or fatigue, it may be helpful to discuss this with your healthcare provider as well. There are many possible causes of fatigue, and your doctor can help determine if there is an underlying medical condition that needs to be addressed. Regarding the medication given to you for regular menstruation, it is important to discuss the effectiveness and potential side effects of the medication with your healthcare provider. They may recommend a different medication or a different course of treatment if the initial medication is not effective or causes unwanted side effects. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician