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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Is The Treatment For Sarcoidosis And Latent Tuberculosis?

My mother aged 59 was diagnosed with Sarcoidosis at GB Pant hospital. The reports showed: -Honey combing of lungs was seen in Xray. -Elevated ACE levels: 67.70 U/L. -Liver Biopsy: Sections show cores of liver tissue with maintained lobular architecture. Many well defined epithelioid cell granulomas are seen in the parenchyma and Portal tracts. Many langhan s and foreign body giant cells are also seen. No caseous necrosis is present. Focal macrovesicular steatosis is seen. After she developed regular coughing she was advised to receive treatment for Latent Tuberculosis. She started DOTS from 21st December 2010. Her coughing was relieved after 2 months of treatment. But Liver Function Test showed: -S.Bilirubin(Total): 8.47 mg/dL -S.G.O.T.(A.S.T): 1,048.70 U/L -S.G.P.T.(A.L.T.): 797.10 U/L -S.Alkaline Phosphatase: 273.01 U/L She was diagnosed with Jaundice and DOTS was stopped. The doctor changed the medicines to ETHAMBUTOL, URSODIOL, OFLOXACIN, STREPTOMYCIN and PANTOSEC. She has been taking the above mentioned medicines for 7 days. Since then she has been suffering from extreme gastric complications, yellow eyes, swollen stomach, loss of appetite and insomnia. She has a history of Gastric problems, Urinary Tract Infection, and she also has an artificial pacemaker installed.
Mon, 8 Aug 2016
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General & Family Physician 's  Response
hi..as your concern your mother has SARCOIDOSIS.
DOTS treatment had produced side effect on LIVER FUNCTION .
your doctor had changed the therapy regime to avoid toxicity of DOTS regime.
its only 7 days so better to have LIVER FUNCTION TEST after 10 -15 day..to see if present side effect is of changed regime or earlier one.
keep repeated LIVER FUNCTION TEST every 15 -20 days to see proper function of liver.
and for gastric problems take medicine with milk or food.
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What Is The Treatment For Sarcoidosis And Latent Tuberculosis?

hi..as your concern your mother has SARCOIDOSIS. DOTS treatment had produced side effect on LIVER FUNCTION . your doctor had changed the therapy regime to avoid toxicity of DOTS regime. its only 7 days so better to have LIVER FUNCTION TEST after 10 -15 day..to see if present side effect is of changed regime or earlier one. keep repeated LIVER FUNCTION TEST every 15 -20 days to see proper function of liver. and for gastric problems take medicine with milk or food.