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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Is The Suggestion For Increased PSA Level Even After Taking Casodex?

i WAS DIAGNOSED WITH STAGE 4 CANCER. AFTER ORCHIECTOMY, i WAS ON CASODEX FOR 3 MONTHS. BEFORE THE OPERATION MY PSA LEVEL WAS 500 (WITH DUTAS-T MEDICATION ). AFTER THAT IT CAME DOWN TO 6. HOWEVER SUBSEQUENT TEST AFTER 4 MONTHS SHOW AN INCREASING TREND. iT WAS 33 ON 21ST OF SEPTEMBER , 2011 AND 48 ON 22ND OF OCTOBE, 2011. I AM ON CASODEX FOR THE PAST 2 MONTHS WITHOUT FINDING LOWERING OF PSA. I AM PHYSICALLY OK, EXCEPT FOR TIREDNESS. I AM 70 YEARS OF AGE. SHOULD i CHANGE OVER TO NEW DRUG?
Wed, 20 Jul 2016
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Urologist,  's  Response
Hello
Thanks for query .

You have been diagnosed to have stage 4 cancer of the Prostate suggesting that the cancer has spread beyond capsule of the prostate to distant locations like bones or other organs ..Cancer of the prostate is hormonal dependent cancer depending upon the Testosterone levels .

.Though Orchidectomy is done there is increase secretion of PSA from the cancer cells spread over to distant locations .

Casodex is anti androgen drug that help to arrest further rise in PSa levels but over a period of time it becomes refractory to the drug resulting into rising trend in PSA levels .

You need to consult qualified medical oncologist to modify the treatment plan and anti cancer drugs.
Dr.patil.
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What Is The Suggestion For Increased PSA Level Even After Taking Casodex?

Hello Thanks for query . You have been diagnosed to have stage 4 cancer of the Prostate suggesting that the cancer has spread beyond capsule of the prostate to distant locations like bones or other organs ..Cancer of the prostate is hormonal dependent cancer depending upon the Testosterone levels . .Though Orchidectomy is done there is increase secretion of PSA from the cancer cells spread over to distant locations . Casodex is anti androgen drug that help to arrest further rise in PSa levels but over a period of time it becomes refractory to the drug resulting into rising trend in PSA levels . You need to consult qualified medical oncologist to modify the treatment plan and anti cancer drugs. Dr.patil.