Hi, Noradrenaline, also known as norepinephrine, is a neurotransmitter and hormone that is involved in various physiological processes, including the regulation of attention, arousal, and stress response. In terms of its effects on cognition, research suggests that noradrenaline has both direct and indirect influences. Noradrenaline acts on several receptors in the brain, including alpha-1, alpha-2, and beta receptors, which are involved in regulating attention, arousal, and learning and memory processes. Increased levels of noradrenaline have been associated with improved cognitive performance in some studies. For example, research has shown that noradrenaline increases alertness, attention, and working memory. It has also been found to enhance learning and memory consolidation by strengthening synaptic connections between neurons. On the other hand, decreased levels of noradrenaline have been associated with impaired cognitive performance, such as reduced attention, impaired working memory, and decreased vigilance. Regarding the influence of noradrenaline on dopamine and serotonin levels, research suggests that there is a complex interplay between these neurotransmitters. Noradrenaline can modulate dopamine and serotonin release in various brain regions, and alterations in noradrenergic activity can affect the release and function of these neurotransmitters. However, the exact nature of these interactions is not fully understood and may depend on the specific brain regions and neurotransmitter systems involved. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician