Hi, I have gone through your medical history carefully and understood your concerns. Epigastric discomfort could be related to gastritis or bowel distension especially if you are also having constipation. Sedentary life is making your bowels lazy, so it would be difficult to get appropriate bowel movement. Apart OTC Zantac, I would recommend as following: - take antacid and simethicone after eating - have your meals regularly although trying to lose weight - have more fiber rich foods (fruits, vegetables, whole grains, etc.) - drink plenty of water - take probiotics to stabilize intestinal flora If still no improvement, should consult further with a gastroenterologist and run upper endoscopy to determine the right diagnosis. Wish fast recovery.