Hello, Thank you for your query. Sorry that you are going through this. Breathing difficulty is a sign of compromised heart function. As you are on medications, I urge you to seek a review with your cardiologist. I recommend: - a cardiologist consult -an echocardiogram and electrocardiogram -blood tests (complete blood count, electrolytes and kidney function tests, Thyroid hormone levels) -urine analysis Sometimes the heart may be too weak even with medications. Different medications may be tried but if they don t work, an artificial pump that helps the heart to pump or a heart transplant will be necessary. The outcomes of these will depend upon your overall health status and needs to be discussed with your doctor. Get a second opinion if your current doctor doesn t offer you treatment options or you are not satisfied. Lupus make it tricky to treat but not impossible. Hope this helps. Please let me know if there is anything else I can help you with. Wish you good health