Hi, The symptoms you are describing, such as shortness of breath, chest heaviness, lightheadedness, and headaches, are concerning and could be due to various medical conditions. The high blood pressure reading you have reported also needs attention. Given your history of Factor V Leiden blood disorder and previous deep vein thrombosis (DVT) in the right leg, it is important to consider the possibility of a pulmonary embolism, which is a blockage in the lung artery that can cause shortness of breath and chest heaviness. Other potential causes of your symptoms include heart conditions like angina or heart attack, lung conditions such as asthma or chronic obstructive pulmonary disease (COPD), and anxiety or panic attacks. It is important to seek medical attention immediately, especially given your history of blood clots. You should go to the emergency room or call your doctor right away. They will evaluate your symptoms, perform necessary tests such as a chest x-ray, electrocardiogram (ECG), and blood tests, and determine the underlying cause of your symptoms. Treatment will depend on the diagnosis but may include medication to manage blood pressure and blood thinners to prevent blood clots. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Regards, Dr. Priyanka, General & Family Physician